Physicochemical, antimicrobial, and cytotoxic characteristics of a chitosan film cross-linked by a naturally occurring cross-linking agent, aglycone geniposidic acid

Journal of Agricultural and Food Chemistry
Fwu-Long MiHsing-Wen Sung

Abstract

The purpose of this study was to evaluate the characteristics of a chitosan film cross-linked by a naturally occurring compound, aglycone geniposidic acid (aGSA). This newly developed aGSA-cross-linked chitosan film may be used as an edible film. The chitosan film without cross-linking (fresh) and the glutaraldehyde-cross-linked chitosan film were used as controls. The characteristics of test chitosan films evaluated were their degree of cross-linking, swelling ratio, mechanical properties, water vapor permeability, antimicrobial capability, cytotoxicity, and enzymatic degradability. It was found that cross-linking of chitosan films by aGSA (at a concentration up to 0.8 mM) significantly increased its ultimate tensile strength but reduced its strain at fracture and swelling ratio. There was no significant difference in the antimicrobial capability between the cross-linked chitosan films and their fresh counterpart. However, the aGSA-cross-linked chitosan film had a lower cytotoxicity, a slower degradation rate, and a relatively lower water vapor permeability as compared to the glutaraldehyde-cross-linked film. These results suggested that the aGSA-cross-linked chitosan film may be a promising material as an edible film.

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Citations

Feb 25, 2010·Journal of Biomaterials Science. Polymer Edition·Jui-Yang LaiGing-Ho Hsiue
Jan 1, 2010·International Journal of Molecular Sciences·Jui-Yang LaiTsu-Pin Wang
Nov 18, 2015·Carbohydrate Polymers·Carol López de DicastilloMaria José Galotto
Apr 22, 2015·Journal of Food Science and Technology·Tarun Pal SinghJhari Sahoo
Jan 24, 2015·Journal of Analytical Methods in Chemistry·Annalisa BiancheraLisa Elviri
Sep 29, 2011·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·J DuttaP K Dutta
Feb 18, 2017·International Journal of Molecular Sciences·Pouria FalamarzpourAkram Zamani
Mar 9, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Cláudia NunesPaula Ferreira
Oct 30, 2019·Artificial Organs·Do Young ParkByoung-Hyun Min
Feb 29, 2020·International Journal of Biological Macromolecules·Sahil ChaudharyRakesh Sharma
Sep 12, 2008·Journal of Agricultural and Food Chemistry·Po-Hui ChenHsyue-Jen Hsieh

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