Physicochemical Characterization and Functional Analysis of the Polysaccharide from the Edible Microalga Nostoc sphaeroides

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Haifeng LiZebo Huang

Abstract

Nostoc colonies have been used as food and medicine for centuries, and their main supporting matrix is polysaccharides, which help Nostoc cells resist various environmental stresses including oxidative stress. Here we isolated a polysaccharide, nostoglycan, from cultured Nostocsphaeroides colonies and determined its physicochemical properties, which revealed a characteristic infrared absorption spectrum typical of polysaccharides and an amorphous morphology with rough surfaces. We also show that nostoglycan has strong moisture absorption and retention capacities and a high relative viscosity. Using Caenorhabditis elegans models, we then demonstrate that nostoglycan is capable of improving overall survival rate of the animals under increased oxidative stress caused by paraquat. Nostoglycan also reduces reactive oxygen species level, inhibits protein carbonyl formation and lipid peroxidation, and increases activities of superoxide dismutase and catalase in paraquat-exposed nematodes. As oxidative stress may drive tumor progression, we further demonstrate that nostoglycan can suppress the proliferation of several types of tumor cells and induce apoptosis of human lung adenocarcinoma A549 cells via caspase-3 activation. Together, o...Continue Reading

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Citations

Nov 20, 2019·International Journal of Molecular Sciences·Sara B PereiraPaula Tamagnini
Jun 25, 2019·International Journal of Biological Macromolecules·Carlos FloresPaula Tamagnini
Dec 13, 2019·Carbohydrate Polymers·Rita MotaPaula Tamagnini
Mar 23, 2021·Frontiers in Pharmacology·Umme Tamanna Ferdous, Zetty Norhana Balia Yusof
Aug 7, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yinlu LiuBo Zhang

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Methods Mentioned

BETA
transgenic
MDA
flow cytometry
Assay

Software Mentioned

ImageXpress
GraphPad Prism
SPSS
GraphPad

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