Physicochemical characterization and in vivo evaluation of triamcinolone acetonide-loaded hydroxyapatite nanocomposites for treatment of rheumatoid arthritis

Colloids and Surfaces. B, Biointerfaces
Samira JafariKhosro Adibkia

Abstract

The current study was aimed to investigate the anti-inflammatory effect of triamcinolone acetonide-loaded hydroxyapatite (TA-loaded HAp) nanocomposites in the arthritic rat model. The HAp nanocomposites were synthesized through a chemical precipitation method and the drug was subsequently incorporated into the nanocomposites using an impregnation method. The physicochemical properties as well as cytotoxicity of the prepared nanoformulation were examined as well. To evaluate the therapeutic efficacy of the prepared nanoformulation, the various parameters such as paw volume, haematological parameters and histological studies were assessed in the arthritic rats. The nanocomposites with the particle size of 70.45 nm, pore size of 2.71 nm and drug loading of 41.94% were obtained in this study. The specific surface area (aBET) as well as the volume of nitrogen adsorbed on one gram of HAp to complete the monolayer adsorption (Vm) were decreased after the drug loading process. The prepared nanoformulation revealed the slower drug release profile compared to the pure drug. Furthermore, the obtained data from MTT assay showed that the TA-loaded nanocomposites had a lower cytotoxic effect on NIH-3T3 and CAOV-4 cell lines as compared to th...Continue Reading

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Citations

Mar 8, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Yulia RyabenkovaAnant Paradkar
Feb 27, 2019·Expert Opinion on Drug Delivery·Solmaz Maleki DizajFarzaneh Lotfipour
Aug 3, 2019·Journal of Biomedical Materials Research. Part a·Quratul AinHussain Ali
Apr 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pakorn Kraisit, Narong Sarisuta
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samira JafariAli Akbar Saboury

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