Abstract
The main purpose of this article is to show the valuable characteristics that liotropic liquid crystal systems possess to be employed as new drug delivery systems. Colloidal aqueous dispersions of lyotropic liquid crystal mesophases such as the identified as cubosomes and hexosomes, and so on, have received considerable attention due to their unique nanostructures and their thermodynamic properties, which provide the potential as a sustained drug release matrix. Additionally, their large surface area and similarity with the liquid crystal structures of intercellular lipids of stratum corneum enhances the interaction with the skin and mucous, increasing the potential for topical drug delivery efficiency of biopharmaceutical class II drugs as the antifungal ketoconazole. This article presents the results in morphological characteristics, particle size, ζ potential, flow, thermal behavior and drug release studies of hexosomes containing ketoconazole (LHLC-K) obtained with glycerol monooleate, propylene glycol monolaurate, poloxamer, and water mixtures. This colloidal system exhibits a Newtonian-type flow and a hexagonal nanostructure with a median particle size of 107 ± 20 nm and ζ potential of +4.45 ± 0.50 mV. Through differentia...Continue Reading
References
Apr 12, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P Costa, J M Sousa Lobo
Jul 10, 2001·The Journal of Investigative Dermatology·S E CrossM S Roberts
Aug 28, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K MoserR H Guy
Jun 5, 2002·Chemical & Pharmaceutical Bulletin·Kyung Ah KooYoung Choong Kim
Jul 30, 2002·Environmental Science & Technology·H Y Sohn, Byung-Su Kim
Jan 27, 2004·Electrophoresis·Brian J Kirby, Ernest F Hasselbrink
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C C Müller-Goymann
Mar 3, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Idit Amar-YuliNissim Garti
Sep 25, 2008·International Journal of Pharmaceutics·Sion A CoulmanJames C Birchall
Apr 8, 2010·The AAPS Journal·Yong ZhangShaofei Xie
Sep 8, 2010·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Bram BaertBart De Spiegeleer
Oct 12, 2010·Drug Discovery Today·Chenyu GuoGuangxi Zhai
Mar 7, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yasmine A GomaaClive G Wilson
Apr 13, 2013·International Journal of Pharmaceutical Investigation·Sb ShirsandD Keerthy
Jul 10, 2014·Drug Delivery·Gerda A JacobsJeanetta du Plessis