Physicochemical characterization of meloxicam-mannitol binary systems

Journal of Pharmaceutical and Biomedical Analysis
P Reisi NassabP Szabó-Révész

Abstract

The dissolution behaviour of drugs remains one of the most challenging aspects in formulation development. The anti-inflammatory drug, meloxicam (ME) has poor water solubility. The object of this experiment was to improve the rate of dissolution of meloxicam in capsule form. In order to achieve this, mannitol was used as a carrier in different ratios, in physical mixtures and melted forms. Mannitol, a sugar alcohol, is a cheap and readily available excipient. Differential scanning calorimetry (DSC) and X-ray diffractometry were used to investigate the characteristics of meloxicam-mannitol binary systems. Multivariate curve resolution (MCR) as a chemometric method was applied to interpret the X-ray diffractograms. This is believed to be the first published use of this reasoning for this interpretation. According to the results, the amount of mannitol and the particle size of ME were important factors in the rate of dissolution. To the perfect dissolution of ME, the melt technology was used which resulted in mixed crystals. This technology was made by 10 parts of mannitol and 1 part of ME2 with about 6 microm in average particle size. The interaction (adhesion) between mannitol and ME for physical mixtures was not enough to the p...Continue Reading

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Citations

Dec 24, 2008·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Garima Chawla, Arvind K Bansal
Aug 21, 2014·International Journal of Pharmaceutics·Masanori OchiNaofumi Hashimoto
Mar 31, 2011·Drug Development and Industrial Pharmacy·Nazik ElgindyAhmed Elzoghby
Jul 10, 2008·Drug Development and Industrial Pharmacy·Amir Bashiri-ShahroodiRóbert Rajkó
Jun 10, 2011·Journal of Pharmaceutical and Biomedical Analysis·Anita PomáziPiroska Szabó-Révész
Jul 21, 2009·International Journal of Pharmaceutics·R AmbrusP Szabó-Révész
Oct 14, 2008·Journal of Pharmaceutical and Biomedical Analysis·Angéla SzutsPiroska Szabó-Révész
May 12, 2016·Drug Development and Industrial Pharmacy·Sonia IurianSorin Leucuta
Apr 20, 2017·Drug Development and Industrial Pharmacy·Tomasz OsmałekKatarzyna Ancukiewicz
Apr 23, 2014·Archives of Pharmacal Research·Saritha Alladi, Nalini R Shastri

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