Physicochemical characterizations of piroxicam-poloxamer solid dispersion

Pharmaceutical Development and Technology
S C Shin, C W Cho

Abstract

To develop an efficient topical delivery system for piroxicam using poloxamer gel formulation, physicochemical behavior of piroxicam in poloxamer was studied. The gelling property of poloxamer and the solubility of piroxicam in the poloxamer were investigated. The interaction between piroxicam and poloxamer was studied by x-ray diffractometry (XRD), infrared (IR) spectroscopy and differential thermal analysis (DTA) with a solid dispersion, coprecipitate, or physical mixture. Poloxamer 407 solutions showed the property of a gel when the concentration was higher than 15% (w/w) and poloxamer 407 increased the aqueous solubility of piroxicam by about 11-fold at the concentration of 22.5% (w/w). The results of XRD did not show the crystalline from of piroxicam in the solid dispersion and results of IR spectroscopic analysis showed an association between functional groups of piroxicam and poloxamer.

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Citations

Nov 9, 2000·Drug Development and Industrial Pharmacy·S ChutimaworapanK Yamamoto
Dec 29, 2006·Drug Development and Industrial Pharmacy·Hadi ValizadehAli Nokhodchi
May 2, 2000·Drug Development and Industrial Pharmacy·S C ShinC W Cho
May 25, 2007·Drug Development and Industrial Pharmacy·Ming Guan PiaoHan-Gon Choi
Aug 15, 2012·Journal of Pharmaceutical and Biomedical Analysis·Fengbin YeJesper Ostergaard
May 10, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fengbin YeJesper Østergaard
Oct 27, 2004·International Journal of Pharmaceutics·Y ChenY D Sanzgiri
Jul 18, 2006·International Journal of Pharmaceutics·Cheong-Weon ChoSang-Chul Shin
Nov 11, 2006·Pharmaceutical Research·Gilles DumortierJean Claude Chaumeil
Apr 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Chiara CristianoDonatella Paolino
Sep 15, 2018·Pharmaceutics·Elena GiulianoDonato Cosco
Mar 21, 2019·Drug Development and Industrial Pharmacy·Yoonho ChoiChong-Kook Kim
Nov 23, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Raj KumarPrem Felix Siril
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenling FanLiuqing Di

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