Physicochemical effects of terpenes on organogel for transdermal drug delivery

International Journal of Pharmaceutics
Perry Fung Chye LimSui Yung Chan

Abstract

It is accepted that terpenes are effective penetration enhancers to promote the passage of drugs or chemicals through the human skin barrier. However the physical and chemical changes of a pharmaceutical vehicle induced by the incorporation of terpenes have not been explored. Thus, this study examines the effects of three terpenes (linalool, cineole, limonene) on the rheology and chemical stability of an organogel composed of dibutyllauroylglutamide (GP1) and propylene glycol (PG). At a given GP1 concentration, oxygen-containing linalool and cineole decreased gel moduli (elastic and viscous) and brittleness, and the reverse was obtained for hydrocarbon limonene. Probably, linalool and cineole interfered with hydrogen bonding between GP1 molecules while limonene could have initiated a phase separation-mediated gelation, changing the gel morphology. Microcalorimetry detected minute heat endotherms for gels (with and without terpenes) subjected to accelerated heat testing. These heat changes could arise from a small degree of structural disruption of the gel network. Heat endotherms normalized with respect to GP1 content were used to assess gel chemical stability. Although the terpenes altered rheology, they did not significantly ...Continue Reading

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Feb 3, 2006·International Journal of Pharmaceutics·Perry Fung Chye LimSui Yung Chan

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Citations

Jun 26, 2009·Expert Opinion on Therapeutic Patents·Abdul AhadSushama Talegaonkar
Jan 13, 2015·Food Chemistry·Jorge A CardonaStephen T Talcott
Jun 23, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Santanu Bhattacharya, Suman K Samanta
Nov 4, 2009·The Journal of Physical Chemistry. B·Jing-Liang Li, Xiang-Yang Liu

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