Physicochemical predictors of Multi-Walled Carbon Nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different Multi-Walled Carbon Nanotubes in mice

Basic & Clinical Pharmacology & Toxicology
Kristina B KnudsenUlla Vogel

Abstract

Multi-walled carbon nanotubes (MWCNT) are widely used nanomaterials that cause pulmonary toxicity upon inhalation. The physicochemical properties of MWCNT vary greatly, which makes general safety evaluation challenging to conduct. Identification of the toxicity-inducing physicochemical properties of MWCNT is therefore of great importance. We have evaluated histological changes in lung tissue 1 year after a single intratracheal instillation of 11 well-characterized MWCNT in female C57BL/6N BomTac mice. Genotoxicity in liver and spleen was evaluated by the comet assay. The dose of 54 μg MWCNT corresponds to three times the estimated dose accumulated during a work life at a NIOSH recommended exposure limit (0.001 mg/m3 ). Short and thin MWCNT were observed as agglomerates in lung tissue 1 year after exposure, whereas thicker and longer MWCNT were detected as single fibres, suggesting biopersistence of both types of MWCNT. The thin and entangled MWCNT induced varying degree of pulmonary inflammation, in terms of lymphocytic aggregates, granulomas and macrophage infiltration, whereas two thick and straight MWCNT did not. By multiple regression analysis, larger diameter and higher content of iron predicted less histopathological chan...Continue Reading

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Citations

Oct 1, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jessica L RayAndrij Holian
Aug 6, 2020·Journal of Clinical Medicine·Valérie Besnard, Florence Jeny
Jan 28, 2020·Environmental Science and Pollution Research International·Fatemeh SamieiJalal Pourahmad
Oct 8, 2020·International Journal of Molecular Sciences·Dorothy J You, James C Bonner
Apr 4, 2021·Cancers·Marcella Barbarino, Antonio Giordano
May 26, 2021·The Science of the Total Environment·Abraão Tiago Batista Guimarães, Guilherme Malafaia
Jul 25, 2021·Particle and Fibre Toxicology·Emilio Di IanniNicklas Raun Jacobsen
Jun 5, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Regitze Sølling WilsPeter Møller

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Methods Mentioned

BETA
ELISA
X‐ray
light microscopy
electrophoresis
dynamic light scattering

Software Mentioned

IMSTAR Pathfinder
SAS
Calculator Plus
ImageJ

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