Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology
Anna NiesciorukAleksandra Misicka

Abstract

Superparamagnetic iron oxide-based nanoparticles (SPIONs) are promising carriers as targeted drug delivery vehicles, because they can be guided to their target with the help of an external magnetic field. Functionalization of nanoparticles' surface with molecules, which bind with high affinity to receptors on target tissue significantly facilitates delivery of coated nanoparticles to their targeted site. Here, we demonstrate conjugation of an antiangiogenic and antitumor peptide ATWLPPR (A7R) to SPIONs modified with sebacic acid (SPIONs-SA). Successful conjugation was confirmed by various analytical techniques (FTIR, SERS, SEM-EDS, TEM, TGA). Cell cytotoxicity studies, against two cell lines (HUVEC and MDA-MB-231) indicated that SPIONs modified with A7R reduced HUVEC cell viability at concentrations higher than 0.01 mg Fe/mL, in comparison to cells that were exposed to either the nanoparticles modified with sebacic acid or A7R peptide solely, what might be partially caused by a process of internalization.

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Citations

Jan 19, 2019·Biomaterials Science·Zhuxuan JiangChangyou Zhan
Nov 2, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Adriana MuchowskaPiotr Kosson

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Methods Mentioned

BETA
xenograft
X-ray
infrared spectroscopy
surface-enhanced Raman scattering
Raman
transmission
dynamic light scattering

Software Mentioned

Prism
GraphPad

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