PMID: 6397555Dec 15, 1984Paper

Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem.

Journal of Lipid Research
A F Hofmann, A Roda

Abstract

The structure of the bile acid molecule is described and correlated with physiochemical properties of bile acids such as solubility, ionization, and micelle formation. Recent measurements of the critical micellar concentration (CMC) of a large number of bile acids indicate that the CMC is influenced by both side chain and nuclear structure. Bile acids with hydroxy substituents on both sides of the steroid nucleus are non-amphipathic and do not form micelles, and decreasing the length of the side chain causes an exponential increase in the CMC. Bile acid ionization, measured by titration in alcohol-water mixtures, is shown to be uninfluenced by nuclear substituents; the pKa of all unconjugated bile acids is about 5. Interactions of bile acid solutions with Ca2+ are discussed; recent work indicates that cholyl conjugates bind Ca2+ as monomers in solution. Model systems relevant to biological processes are classified, as are some of the physicochemical parameters of these systems. Biological processes involving bile acids are tabulated, and corresponding model systems are assigned to each. Some biological processes such as bile acid transport show marked species differences, suggesting that physicochemical parameters are insuffici...Continue Reading

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