Physicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine

Scientific Reports
Sophie N B Selby-PhamLouise E Bennett

Abstract

A diet high in phytochemical-rich plant foods is associated with reducing the risk of chronic diseases such as cardiovascular and neurodegenerative diseases, obesity, diabetes and cancer. Oxidative stress and inflammation (OSI) is the common component underlying these chronic diseases. Whilst the positive health effects of phytochemicals and their metabolites have been demonstrated to regulate OSI, the timing and absorption for best effect is not well understood. We developed a model to predict the time to achieve maximal plasma concentration (Tmax) of phytochemicals in fruits and vegetables. We used a training dataset containing 67 dietary phytochemicals from 31 clinical studies to develop the model and validated the model using three independent datasets comprising a total of 108 dietary phytochemicals and 98 pharmaceutical compounds. The developed model based on dietary intake forms and the physicochemical properties lipophilicity and molecular mass accurately predicts Tmax of dietary phytochemicals and pharmaceutical compounds over a broad range of chemical classes. This is the first direct model to predict Tmax of dietary phytochemicals in the human body. The model informs the clinical dosing frequency for optimising uptak...Continue Reading

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Citations

Jul 15, 2017·Nutrients·Sophie N B Selby-PhamKate S Howell
Jan 7, 2020·Current Drug Metabolism·Pooja Rathaur, Kaid Johar Sr
Oct 10, 2018·Frontiers in Nutrition·Hannah CoryJosiemer Mattei
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Yit Tao LooKen Ng
Apr 1, 2021·Critical Reviews in Food Science and Nutrition·Fereidoon Shahidi, Yao Pan
Jun 23, 2021·Critical Reviews in Food Science and Nutrition·Soon-Sen LeowRavigadevi Sambanthamurthi
Jun 22, 2021·Bioorganic & Medicinal Chemistry·Helmut M HügelAnthony Lingham
Aug 4, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Oi Jin TanUsha Sundralingam
Jul 8, 2020·Journal of Agricultural and Food Chemistry·Zeynep GoktasShu Wang
Jan 8, 2020·ACS Chemical Neuroscience·Joel FrandsenPrabagaran Narayanasamy

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