Physicochemical properties of the high-field MRI-relevant [Gd(DTTA-Me)(H2O)2]- complex

Inorganic Chemistry
Loïck MoriggiLothar Helm

Abstract

To study the physicochemical properties of the DTTA chelating moiety (H4DTTA = diethylenetriaminetetraacetic acid = N,N'-[iminobis(ethane-2,1-diyl)]bis[N-(carboxymethyl)glycine]), used in several compounds proposed as magnetic resonance imaging (MRI) contrast agents, the methylated derivative H4DTTA-Me (N,N'-[(methylimino)bis(ethane-2,1-diyl)]bis[N-(carboxymethyl)glycine]) was synthesized. Protonation constants of the ligand were determined in an aqueous solution by potentimetry and (1)H NMR pH titration and compared to various DTTA derivatives. Stability constants were measured for the chelates formed with Gd(3+) (log K(GdL) = 18.60 +/- 0.10) and Zn(2+) (log K(ZnL) = 17.69 +/- 0.10). A novel approach of determining the relative conditional stability constant of two paramagnetic complexes in a direct way by (1)H NMR relaxometry is presented and was used for the Gd(3+) complexes [Gd(DTTA-Me)(H2O)2](-) (L1) and [Gd(DTPA-BMA)(H2O)] (L2) [K(L1/L2)*(at pH 8.3, 25 degrees C) = 6.4 +/- 0.3]. The transmetalation reaction of the Gd(3+) complex with Zn(2+) in a phosphate buffer solution (pH 7.0) was measured to be twice as fast for [Gd(DTTA-Me)(H2O)2](-) in comparison to that for [Gd(DTPA-BMA)(H2O)]. This can be rationalized by the highe...Continue Reading

References

Jan 1, 1992·Critical Care Medicine·B A Mizock, J L Falk
Jan 1, 1990·Magnetic Resonance Imaging·W P CacherisS M Rocklage
Oct 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A D SherryK T Kuan
Nov 24, 2004·Inorganic Chemistry·Silvio AimeMassimo Sisti
Nov 18, 2005·Advanced Drug Delivery Reviews·Hisataka Kobayashi, Martin W Brechbiel
Nov 29, 2005·Chemistry : a European Journal·João Bruno LivramentoEva Tóth
Feb 14, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Zoltán JászberényiTamás Kálai
Dec 29, 2006·Contrast Media & Molecular Imaging·Sophie LaurentRobert N Muller
Jan 12, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Zoltán JászberényiEva Tóth
May 18, 2007·Kidney International·T Grobner, F C Prischl
Jun 6, 2007·Internal Medicine Journal·Z H Endre
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Mark A Perazella
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Hale Ersoy, Frank J Rybicki
Feb 20, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·João Bruno LivramentoEva Tóth

❮ Previous
Next ❯

Citations

Nov 3, 2011·Chemical Communications : Chem Comm·Joel GarciaMatthew J Allen
Sep 17, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Hugues JaccardLothar Helm
Sep 24, 2015·Inorganic Chemistry·Attila ForgácsCarlos Platas-Iglesias
May 23, 2015·The Journal of Physical Chemistry. a·Martín Regueiro-Figueroa, Carlos Platas-Iglesias
Mar 23, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Morgane EnelClaude Picard
Dec 15, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Bedika PhukanRaunak Varshney
Feb 9, 2016·Contrast Media & Molecular Imaging·Kido NweAndrew Tsourkas
Jun 11, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Sara SilvérioCarlos F G C Geraldes
Sep 11, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Gaylord TallecMarinella Mazzanti
Aug 2, 2013·Chemical Communications : Chem Comm·Eric M GalePeter Caravan
Sep 3, 2009·Journal of the American Chemical Society·Loïck MoriggiLothar Helm

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.