Physicochemical properties, pharmacokinetics, and biodistribution of gadoteridol injection in rats and dogs

Academic Radiology
M N EakinsC W Thompson

Abstract

The physicochemical properties of gadoteridol, a macrocyclic nonionic gadolinium complex, were studied together with its pharmacokinetics and biodistribution in rats and dogs. Studies in rats were conducted after single intravenous injections at 0.1 or 0.35 mmol/kg using 153Gd-labeled gadoteridol or with seven daily doses of 0.1 mmol/kg to examine the levels of residual gadolinium in organs. Nonradioactive biodistribution and excretion studies were performed in dogs following injection at 0.1 mmol/kg. After injection, the dose was rapidly cleared from rat blood and excreted such that more than 90% of the dose appeared in the urine within 4 hr of injection. At 7 and 14 days postinjection, only extremely low levels of gadolinium were observed in liver and bone; these levels were two to eight times lower than the levels reported after the injection of gadopentetate dimeglumine. The extracellular distribution and rapid urinary excretion of gadoteridol is in agreement with data obtained with other gadolinium-containing chelates used as intravascular magnetic resonance imaging contrast agents. Differences observed in the long-term retention of gadolinium between gadoteridol and gadopentetate dimeglumine were consistent with the repor...Continue Reading

References

Jan 1, 1992·Magnetic Resonance Imaging·P WedekingM F Tweedle
Jan 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·C A ChangK N Raymond
Jan 1, 1991·Magnetic Resonance Imaging·M F TweedleC A Chang
Mar 1, 1991·Radiology·M F Tweedle
Jun 1, 1990·AJR. American Journal of Roentgenology·U SchmiedlC A Dowling
Jan 1, 1990·Magnetic Resonance Imaging·W P CacherisS M Rocklage
Jun 1, 1989·Investigative Radiology·J R Coveney, M S Robbins
Apr 1, 1974·Journal of Pharmacokinetics and Biopharmaceutics·H G BoxenbaumR M Elashoff
Mar 1, 1984·AJR. American Journal of Roentgenology·H J WeinmannG E Wesbey
Jan 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·P W DURBINJ G HAMILTON

❮ Previous
Next ❯

Citations

Apr 20, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mariska de SmetHolger Grüll
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ratchapol JenjobSu-Geun Yang
Oct 29, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Frits ThorsenKatherine W Ferrara
Nov 10, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mariska de SmetHolger Grüll

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.