Physicochemical Stability and Sterility of Standard Parenteral Nutrition Solutions and Simulated Y-Site Admixtures for Neonates

Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
Pau RieraNoe Garin

Abstract

Parenteral nutrition (PN) is frequently needed in neonatal intensive care. The use of standard PN has emerged as an easy-to-prescribe approach that allows one to have on-site, ready-to-use PN. The aim of this study was to test the physicochemical stability and sterility of 2 specific PN solutions as well as simulate Y-site compatibility with lipid injectable emulsions (ILE). Our study considered 2 standard ILE-free PN solutions according to neonatal weight. These solutions were prepared in duplicate and stored at 4°C. The following physicochemical parameters were tested: visual alterations, turbidity, pH, osmolarity, and calcium concentration. Sterility was assessed by means of agar blood culture and glucose concentration determination. In addition, we assessed the stability of simulated Y-site admixtures. For each standard ILE-free PN solution, 2 3-in-1 PN admixtures were designed, considering extreme values of fluid requirements (50 and 150 ml/kg/d) and a fat supply of 2 g/kg/24 h. The physicochemical parameters tested were phase separation and fat mean droplet size distribution. No alterations were detected by visual inspection. Calcium concentrations, turbidity, pH, and osmolarity values remained stable in all the determina...Continue Reading

References

Jun 13, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·O MontejoJ Bonal
Apr 15, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Antònia BaletMa Antònia Mangues
May 26, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Mansi J ParikhDavid F Driscoll
Jul 28, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·John A Kerner, Robert L Poole
Apr 15, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Maria SkouroliakouNikolaos Andrikopoulos
Oct 9, 2008·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M IshizukaK Kubota
Jan 29, 2010·International Journal of Medical Sciences·Takashi KuwaharaYoshifumi Inoue
May 22, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lucie BouchoudPascal Bonnabry
Jun 23, 2010·International Journal of Medical Sciences·Takashi KuwaharaYoshifumi Nakashima
Aug 27, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Christos AthanasiouSophia Markantonis-Kyroudis
Feb 18, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph I BoullataUNKNOWN American Society for Parenteral and Enteral Nutrition
Feb 24, 2015·Clinical Medicine Insights. Pediatrics·Ghassan Sa SalamaMohammad Ia Alquran
Apr 11, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Allison Beck Blackmer, M Luisa Partipilo

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Citations

Mar 9, 2019·Nutrients·Maciej StawnyMagdalena Ogrodowczyk
Nov 7, 2020·Nutrición hospitalaria·Mar Tripiana RalloRaúl Ferrando Piqueres
Nov 4, 2020·Nutrition·Katarzyna DettlaffMagdalena Ogrodowczyk

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