Physicochemical stability of norepinephrine bitartrate in polypropylene syringes at high concentrations for intensive care units

Annales pharmaceutiques françaises
E D'HuartB Demore

Abstract

Norepinephrine is usually used in emergency situations such as in intensive care units (ICUs) for the restoration of blood pressure. The objective was to study the stability of highly-concentrated solutions of norepinephrine at 0.50mg/mL and 1.16mg/mL, diluted in glucose 5% (G5%) in polypropylene syringes, protected or not from light, up to 48h. Chemical stability was analysed by high-performance liquid chromatography coupled to photodiode array detection at each time of the analysis. The method was validated according to the International Conference on Harmonisation Q2(R1). Physical stability was evaluated by visual and subvisual inspection. Three syringes for each condition were prepared. At each time of the analysis, three samples were analysed for each syringe. pH values were evaluated at each moment of the analysis. Solutions of norepinephrine at 0.50 and 1.16mg/mL, diluted in G5%, with or without protection from light, retained more than 95.0% of the initial concentration after a 48-hour storage at 20-25°C. No visual and subvisual modification occured during the stability study. No degradation product appearing during the stressed degradation was observed during the study but an additional peak with a relative retention a...Continue Reading

References

Oct 1, 1991·Journal of Clinical Pharmacy and Therapeutics·M C Allwood
Jun 15, 1997·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·T E PeddicordL Webb
Aug 16, 2011·Annales pharmaceutiques françaises·C BardinUNKNOWN French Society of Oncology Pharmacy

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Citations

Apr 17, 2020·European Journal of Hospital Pharmacy. Science and Practice·Sixtine GilliotPascal Odou
Apr 17, 2020·European Journal of Hospital Pharmacy. Science and Practice·Elise D'HuartBéatrice Demoré
Apr 17, 2020·European Journal of Hospital Pharmacy. Science and Practice·Benoît BeilerBéatrice Demoré

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