Physiologic basis and pathophysiologic implications of the diastolic properties of the cardiac muscle.

Journal of Biomedicine & Biotechnology
João Ferreira-Martins, Adelino F Leite-Moreira

Abstract

Although systole was for long considered the core of cardiac function, hemodynamic performance is evenly dependent on appropriate systolic and diastolic functions. The recognition that isolated diastolic dysfunction is the major culprit for approximately fifty percent of all heart failure cases imposes a deeper understanding of its underlying mechanisms so that better diagnostic and therapeutic strategies can be designed. Risk factors leading to diastolic dysfunction affect myocardial relaxation and/or its material properties by disrupting the homeostasis of cardiomyocytes as well as their relation with surrounding matrix and vascular structures. As a consequence, slower ventricular relaxation and higher myocardial stiffness may result in higher ventricular filling pressures and in the risk of hemodynamic decompensation. Thus, determining the mechanisms of diastolic function and their implications in the pathophysiology of heart failure with normal ejection fraction has become a prominent field in basic and clinical research.

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Citations

Jan 26, 2012·Seminars in Dialysis·Roberto Pecoits-FilhoSilvio H Barberato
Apr 29, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tetsuya OgawaKosaku Nitta
Oct 21, 2016·Cardiovascular Drugs and Therapy·Catarina FranciscoAdelino Leite-Moreira
Feb 5, 2021·Journal of the American College of Cardiology·Albert E Raizner, Miguel A Quiñones

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