PMID: 3335710Jan 1, 1988Paper

Physiologic correlates of the heart rate response to upright isotonic exercise: relevance to rate-responsive pacemakers

Journal of the American College of Cardiology
P A McElroyK T Weber

Abstract

Rate-responsive cardiac pacing requires a sensitive physiologic variable that is closely correlated with the heart rate-oxygen uptake relation, particularly in patients with heart failure whose cardiac output response to exercise is more dependent on heart rate. Accordingly, the heart rate response to upright exercise was measured in 81 patients with heart failure or hypertension, or both, and in 27 normal subjects. Oxygen uptake (VO2), minute ventilation (VE), cardiac output, right heart pressures and the mixed venous temperature, oxygen saturation (SvO2) and pH were analyzed throughout exercise. Linear regression analysis of these variables with heart rate revealed the following: 1) There was a highly linear heart rate-VO2 relation in each subject (the average slope of this relation was greater [p less than 0.05] in patients with more severe failure). 2) VE was highly correlated with exercise heart rate, and its slope was not different between normal subjects and patients. 3) Mixed venous temperature and pH were poor predictors of exercise heart rate, particularly at low or moderate levels of work; however, SvO2 was highly correlated with heart rate for all levels of work. Thus, in normal subjects and patients with heart fail...Continue Reading

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Citations

Mar 1, 1993·Clinical Cardiology·D KatritsisA J Camm
Jan 3, 1997·International Journal of Cardiology·H OhuchiT Kamiya
Aug 1, 1993·Pacing and Clinical Electrophysiology : PACE·N TreeseJ Meyer
Mar 1, 1993·Pacing and Clinical Electrophysiology : PACE·R G CharlesB L Westrum
Mar 9, 2011·Circulation·Peter H Brubaker, Dalane W Kitzman
May 2, 2007·Current Cardiology Reports·Peter H Brubaker, Dalane W Kitzman
Feb 1, 2008·Pacing and Clinical Electrophysiology : PACE·Justin D ShaberSoo G Kim
Apr 23, 2016·Journal of the American College of Cardiology·Haqeel A JamilKlaus K Witte
Sep 10, 2005·Seminars in Cardiothoracic and Vascular Anesthesia·Neil K Anand, David P Maguire
Dec 10, 1999·Pacing and Clinical Electrophysiology : PACE·B SchwaabH Schieffer
Jan 23, 1999·Pacing and Clinical Electrophysiology : PACE·B SchwaabH Schieffer
Nov 1, 1988·Pacing and Clinical Electrophysiology : PACE·H MondG Baker
Oct 1, 1989·Pacing and Clinical Electrophysiology : PACE·L JordaensD L Clement
Aug 1, 1993·Pacing and Clinical Electrophysiology : PACE·A M AbrahamsenK Dickstein
Aug 1, 1997·Pacing and Clinical Electrophysiology : PACE·L P SoucieA S Tang
Dec 11, 1990·Pacing and Clinical Electrophysiology : PACE·S M YabekB McWilliams
Dec 27, 2019·Pacing and Clinical Electrophysiology : PACE·Maria SerovaHugo Saner
Mar 7, 2021·The Veterinary Journal·N Sydney MoïseRomain Pariaut

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