PMID: 9542750Jun 6, 1998Paper

Physiologic doses of urocanic acid do not alter the allostimulatory function or the development of murine dendritic cells in vitro

Photodermatology, Photoimmunology & Photomedicine
M B LappinJ C Simon

Abstract

Exposure to UVB results in the isomerization of trans-urocanic acid (UCA), localized in the stratum corneum, to cis-UCA. Cis-UCA can mediate at least some of the immunosuppressive effects of UVB, though the mechanism of cis-UCA action remains incompletely defined. Alterations in Langerhans cells, and other dendritic antigen presenting cell populations in the skin, may contribute to the loss of skin immune function following UVB exposure. Hence, this study was designed to investigate whether cis-UCA directly can induce changes in the immunostimulatory capacity of dendritic cells (DC) and the development of DC from precursor cells. Murine DC were generated from C57BL/6 bone marrow (BM) using granulocyte-macrophage colony-stimulating factor (GM-CSF), and were used as stimulator cells in mixed lymphocyte reactions (MLR) using BALB/c lymph node cells (LNC) as responders. The addition of cis- and trans-UCA at concentrations ranging from 0.1-500 micrograms/ml to the MLR did not affect proliferative responses. Cis- or trans-UCA (100 micrograms/ml) was added to GM-CSF stimulated mouse BM cells on day 0, day 3 or day 5 of culture, and the phenotype and allo-stimulatory function of the DC were analysed on day 7. Treatment with cis- or tra...Continue Reading

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Citations

Apr 3, 2010·Journal of Molecular Modeling·Saumya Tiwari, Phool Chand Mishra
Jun 19, 2001·Biochimica Et Biophysica Acta·A KammeyerM B Teunissen
Sep 15, 1999·Allergy·N NovakT Bieber
Nov 18, 2003·Photodermatology, Photoimmunology & Photomedicine·M R PraterS D Holladay
Apr 3, 2001·Photochemistry and Photobiology·M Zak-PrelichR C McKenzie
Sep 2, 2004·Photochemistry and Photobiology·Arthur KammeyerMarcel B M Teunissen
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S BeissertT Schwarz

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