Physiologic-insensitive left ventricular assist predisposes right-sided circulatory failure: a pilot simulation and validation study

Artificial Organs
Koen ReesinkErik van der Veen

Abstract

Right-sided circulatory failure (RSCF) is a serious complication in 15-30% of patients receiving a left ventricular assist device (LVAD). It is hypothesized that left ventricular support which lacks physiologic properties predisposes to RSCF. An integral computer simulation and experimental validation protocol was performed. The results suggest that with conventional insensitive left ventricular support right-sided circulatory function is compromised, which may form a substrate for the onset or progress of RSCF. Feedback control of the LVAD could provide a means to counter this problem. A control concept for the LVAD which aims to preserve right-sided circulatory function, while supporting peripheral perfusion, is proposed

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Citations

Feb 24, 2005·Artificial Organs·Paul S Malchesky
Oct 31, 2008·Artificial Organs·Daniel TimmsMark Pearcy
Apr 12, 2012·Artificial Organs·Einly LimNigel H Lovell
Sep 23, 2009·IEEE Transactions on Bio-medical Engineering·Einly LimNigel H Lovell
May 23, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Francesco M ColacinoGuido A Danieli

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