Physiologic response to a protein, carbohydrate, fat meal in patients with human immunodeficiency virus who underwent small intestinal enteropathy as characterized by a kinetic model of D-xylose absorption

JPEN. Journal of Parenteral and Enteral Nutrition
S J CarlsonR M Craig

Abstract

Small intestinal human immunodeficiency virus enteropathy is characterized by profound absorptive dysfunction unrelated to histology or pathogens. Frequently an attempt is made to compensate for this intestinal failure by supplementing nutrient intake with nourishing liquid meals. It is not known how the diminished absorptive function in these patients will respond to this intake. With the use of a D-xylose kinetic model of absorption, we determined the absorptive response of patients with small intestinal enteropathy to an isotonic liquid feeding. Seven male patients with acquired immunodeficiency syndrome (AIDS), diarrhea, weight loss, and no detectable pathogens (stool studies and duodenal biopsy) were enrolled. After an overnight fast, the patients were studied on three separate days. On day 1, the patients received 15 g oral D-xylose. On day 2, 10 g i.v. D-xylose was given. On day 3, 15 g oral D-xylose was again given along with 250 mL of a liquid polymeric isotonic diet. Serum and urine collections were obtained to calculate the kinetic rate constants and extent of D-xylose absorption. Mean values for the rate constant for absorption of D-xylose, Ka, (0.26/h; N > 0.65) and the rate constant for nonabsorptive loss, K0' (2....Continue Reading

References

Jun 1, 1991·Clinical Pharmacology and Therapeutics·E D EhrenpreisA J Atkinson
Oct 1, 1994·Digestive Diseases and Sciences·E D EhrenpreisR M Craig
Aug 1, 1993·Digestive Diseases and Sciences·G R MayL R Sutherland
Oct 1, 1993·Gastroenterology·D Simon, L J Brandt

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Citations

Apr 13, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P PierucciC Sabbà
Sep 6, 2011·The Veterinary Clinics of North America. Small Animal Practice·Stephen J Mehler
Oct 28, 2019·Histochemistry and Cell Biology·A GomesA Marques-Ramos

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