PMID: 2122376Sep 1, 1990Paper

Physiologic status of regenerated hair cells in the avian inner ear following aminoglycoside ototoxicity

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
D L Tucci, E W Rubel

Abstract

Regeneration of avian inner ear hair cells has been demonstrated after administration of aminoglycoside and after acoustic trauma. However, no published study to date has documented functional recovery of these regenerated sensory receptor cells. Newborn chicks were treated with gentamicin sulfate (50 mg/kg/day) for a total of either 5 (n = 10) or 10 (n = 76) days. Evoked potential thresholds were obtained one day after the 5-day treatment, or at intervals between one day and 20 weeks after the 10-day treatment course, and compared to thresholds of age-matched control animals. A significant hearing loss, predominantly in the high frequencies, was present after as few as 5 days of drug administration. The magnitude of hearing loss continued to increase, especially at lower frequencies, as survival increased from 1 day to 5 weeks after gentamicin treatment. Sixteen-to-20 weeks after treatment, partial recovery of thresholds was evident. These findings demonstrate that functional recovery does occur in the avian inner ear following aminoglycoside administration. Recovery occurs at all frequencies, but predominantly at low and middle frequencies, leaving significant residual high-frequency threshold elevation. Recovery lags 14 to 1...Continue Reading

References

Sep 1, 1978·Acta Oto-laryngologica·O WinkelK Rozarth
Jun 1, 1977·The Journal of Laryngology and Otology·D A Moffat, R T Ramsden
Sep 1, 1989·Hearing Research·E A McFadden, J C Saunders
Jan 1, 1987·Acta Oto-laryngologica. Supplementum·E H Huizing, J C de Groot
Jun 24, 1988·Science·J T Corwin, D A Cotanche
Oct 1, 1987·Archives of Otolaryngology--head & Neck Surgery·R M CruzE W Rubel
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J T Corwin
Jul 1, 1984·The Journal of Cell Biology·L G Tilney, M S Tilney
Oct 1, 1981·The Journal of Comparative Neurology·J T Corwin
Oct 1, 1980·The Laryngoscope·W E Fee

❮ Previous
Next ❯

Citations

Jul 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M MüllerR Klinke
Jun 24, 1999·Journal of Neurobiology·H R WilkinsA N Popper
Jun 26, 2009·The Laryngoscope·Christina L KaiserDouglas A Cotanche
May 30, 2009·The Laryngoscope·Eric MeenTaeed Quddusi
Feb 15, 2014·Audiology & Neuro-otology·Hendrik G BremerSjaak F L Klis
Dec 19, 2018·Cold Spring Harbor Perspectives in Medicine·Corné J Kros, Peter S Steyger
Jun 19, 1996·Annals of the New York Academy of Sciences·J P CareyE W Rubel
May 1, 1993·The Journal of Comparative Neurology·P Weisleder, E W Rubel
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J DoolingK Manabe
Jul 30, 2010·NMR in Biomedicine·Geert De Groof, Annemie Van der Linden
May 1, 1993·The Journal of Comparative Neurology·L G Duckert, E W Rubel
Jun 8, 2000·Annals of the New York Academy of Sciences·A QuarantaA Scaringi
Apr 29, 2006·The Journal of the Acoustical Society of America·Robert J DoolingTracy L Reid
Jan 29, 2010·Journal of the Association for Research in Otolaryngology : JARO·Thomas J Bell, John Carl Oberholtzer
Feb 23, 1999·Journal of Neurobiology·B H Sokolowski, A M Cunningham
Jul 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S Masetto, M J Correia
Aug 18, 2004·Annals of the New York Academy of Sciences·Sarah M N Woolley
Jan 20, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Roberto AlberaMichele Lanotte
Nov 22, 2011·Stem Cells·Mohammad RonaghiStefan Heller
Feb 3, 1995·Science·E W RubelD W Roberson
Jul 1, 1996·The Journal of Comparative Neurology·M S Ofsie, D A Cotanche
Sep 1, 1994·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·T T TsueE W Rubel
Mar 25, 2021·Cell Reports·Nesrine BenkafadarStefan Heller
Jan 11, 2002·Developmental Biology·O Bermingham-McDonoghE W Rubel
Nov 5, 1999·Hearing Research·U LangemannA Friebe
Feb 21, 2003·Current Opinion in Neurobiology·Olivia Bermingham-McDonogh, Edwin W Rubel
Oct 1, 1993·Hearing Research·E C OesterleE W Rubel
Feb 1, 1992·Hearing Research·Y E CohenJ C Saunders
Aug 1, 1994·Current Opinion in Neurobiology·D A Cotanche, K H Lee
Jan 1, 1992·Experimental Neurology·Y Raphael, R A Altschuler
May 6, 2008·Journal of Communication Disorders·Douglas A Cotanche
Apr 30, 1993·Science·P P LefebvreT R Van de Water

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.