PMID: 2485029Jan 1, 1987Paper

Physiologic versus pathologic hypertrophy and the pressure-overloaded myocardium

Journal of Cardiovascular Pharmacology
K T WeberS G Shroff

Abstract

The myocardium consists of myocytes and capillaries embedded in a connective tissue matrix. Myocardial mass, which is predominantly a function of myocyte size, is determined by systolic tension; when systolic pressure is gradually elevated above the normal range, mass will increase. The hypertrophic process is a continuum consisting of subtle transitions that take place within the muscular, collagenous, and vascular compartments; these transitions, however, need not be temporarily concordant. We would identify three phases to the hypertrophic process. First, there is an evolutionary phase, whereby the structural and biochemical remodeling of the various compartments of the myocardium is in transition, with each compartment having its own rate of adjustment. During this evolutionary phase, myocardial contractility, as reflected by stress-length and stress-velocity relations, may or may not be normal, but ventricular pump function and O2 delivery are preserved. Second, there is a physiologic phase during which the structural and biochemical remodeling of the compartments reaches a coordinated balance. The myocardial stress-length relation and ventricular function are each normal, but rate-dependent indices of contractility may be...Continue Reading

Citations

Jun 1, 1989·Journal of the American College of Cardiology·K T Weber
Apr 6, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Maria Lonnett BurgessThomas K Borg
Dec 18, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Henrik EngblomHåkan Arheden
Feb 24, 2001·Journal of Anatomy·K A LinehanP E Williams
Mar 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Jane BlackMary E Wlodek
Mar 1, 1995·Annals of Biomedical Engineering·J H OmensJ W Covell
Sep 15, 2006·The International Journal of Cardiovascular Imaging·Massimo LeggioFrancesco Leggio
Apr 6, 2001·Clinical Cardiology·P CarsonH M Siragy
Aug 19, 2011·Heart Failure Reviews·Naranjan S DhallaVijayan Elimban
Jan 19, 2016·Journal of Molecular and Cellular Cardiology·Iñigo Valiente-AlandiBurns C Blaxall
May 20, 2009·Journal of Molecular and Cellular Cardiology·S RimbaudR Ventura-Clapier
Dec 8, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J Jason ClarkKenneth J Rodnick
Nov 2, 2005·International Journal of Cardiology·Giuseppe LimongelliFrancesco Mario Limongelli
Jan 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H N SoufenC Mady
May 4, 2001·International Journal for Parasitology·S B PetkovaH B Tanowitz
May 13, 2017·The Journal of Experimental Biology·Elizabeth F Johnston, Todd E Gillis
Aug 2, 2003·Journal of Cellular Physiology·Melissa Joy LoftisWayne Carver
Dec 1, 1990·Circulation Research·C G BrillaK T Weber
May 1, 1990·Circulation Research·J M CapassoP Anversa
Mar 29, 2007·Hypertension·Gerald W Dorn
Feb 1, 1995·Hypertension·L Cao, D G Gardner
Apr 19, 2013·Critical Reviews in Biochemistry and Molecular Biology·Karen L Gamble, Martin E Young
Sep 16, 2017·Expert Review of Cardiovascular Therapy·Ming-Sing Si, Richard G Ohye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.