Abstract
Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations of aldosterone and certain components of the lipid metabolism in the peripheral circulation were suggested, but data from the general population is sparse. We therefore aimed to assess the associations between aldosterone and HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, or non-HDL-C in the general adult population. Data from 793 men and 938 women aged 25-85 years who participated in the first follow-up of the Study of Health in Pomerania were obtained. The associations of aldosterone with serum lipid concentrations were assessed in multivariable linear regression models adjusted for sex, age, body mass index (BMI), estimated glomerular filtration rate (eGFR), and HbA1c. The linear regression models showed statistically significant positive associations of aldosterone with LDL-C (β-coefficient = 0.022, standard error = 0.010, p = 0.03) and non-HDL-C (β-coefficient = 0.023, standard error = 0.009, p = 0.01) as well as an inverse association of aldosterone with HDL-C (...Continue Reading
References
Jan 1, 1995·Hypertension·T L GoodfriendD L Ball
Sep 2, 1999·The New England Journal of Medicine·B PittJ Wittes
Feb 27, 2004·Cardiovascular Research·Allan D Struthers, Thomas M MacDonald
Jul 2, 2004·The New England Journal of Medicine·Ramachandran S VasanDaniel Levy
Mar 18, 2005·Journal of Cardiovascular Pharmacology·Giovanni GaudioAchille Venco
May 11, 2005·American Journal of Hypertension·Sekar KathiresanRamachandran S Vasan
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Roberto TrevisanGiuseppe Lepore
Jun 21, 2006·Hypertension·Murielle BochudMichel Burnier
Nov 23, 2006·Circulation·Farzin BeyguiGilles Montalescot
Feb 27, 2007·The American Journal of Medicine·Sidney C Smith
Mar 21, 2007·Circulation·Gülmisal GüderStefan Störk
Mar 27, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Massimiliano CaprioMaria-Christina Zennaro
Aug 19, 2007·Circulation·Erik IngelssonRamachandran S Vasan
Jan 6, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M QuinklerV G Fourkiotis
Feb 17, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A HannemannH Wallaschofski
Feb 20, 2010·International Journal of Epidemiology·Henry VölzkeWolfgang Hoffmann
Mar 2, 2011·European Journal of Endocrinology·Anke HannemannMartin Reincke
Jun 13, 2013·Diabetes Care·Solomon K MusaniErvin R Fox
Jul 16, 2014·International Journal of Endocrinology·Atil Y Kargi, Gianluca Iacobellis
Feb 4, 2016·Current Hypertension Reports·Andrea VecchiolaCarlos E Fardella
Mar 5, 2016·The Journal of Clinical Endocrinology and Metabolism·John W FunderWilliam F Young
May 12, 2016·Kidney International·Nosratola D Vaziri
Oct 21, 2016·Endocrine·Christian AdolfMartin Reincke
May 12, 2017·International Journal of Molecular Sciences·John W Funder
Sep 16, 2017·Comprehensive Physiology·Marco InfanteMassimiliano Caprio
Citations
Nov 9, 2018·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tomasz PizońDanuta Czarnecka
Jun 18, 2019·Journal of Hypertension·Antonio ConcistrèClaudio Letizia
May 28, 2020·Lipids in Health and Disease·Bojko BjelakovicMaciej Banach
Jul 2, 2021·International Journal of Endocrinology·Xiaoyu HuangXiaopei Cao
Aug 7, 2021·Journal of Cardiovascular Development and Disease·Nasim KiaieAmirhossein Sahebkar