Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder

Molecular Neurobiology
Yuan-Yang Lai, Jerome M Siegel

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease that is caused by a loss of neurons in the ventral midbrain. Parkinsonian patients often experience insomnia, parasomnias, and daytime somnolence. REM sleep behavior disorder (RBD) is characterized by vigorous movements during REM sleep, and may also be caused by neuronal degeneration in the central nervous system (CNS); however, the site of degeneration remains unclear. Both Parkinsonism and RBD become more prevalent with aging, with onset usually occurring in the sixties. Recent findings show that many individuals with RBD eventually develop Parkinsonism. Conversely, it is also true that certain patients diagnosed with Parkinsonism subsequently develop RBD. Postmortem examination reveals that Lewy bodies, Lewy neurites, and alpha-synuclein are found in brainstem nuclei in both Parkinsonism and RBD patients. In this article, we will discuss evidence that Parkinsonism and RBD are physiologically and anatomically linked, based on our animal experiments and other studies on human patients.

Citations

Oct 13, 2006·Archives of Neurology·Keith A JosephsRonald C Petersen
Jan 25, 2008·Journal of Neurology·Marie-Helene MarionOliver Foster
Jan 23, 2013·Journal of Neural Transmission·Martina KrenzerWolfgang Oertel
Mar 16, 2007·Current Neurology and Neuroscience Reports·Mark W MahowaldMichel A Cramer Bornemann
Sep 12, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael J Howell
Apr 25, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Norman WolkoveMark Palayew
Feb 9, 2012·Chest·Mark Eric DykenDeborah C Lin-Dyken
Apr 13, 2013·Lancet Neurology·Mark W Mahowald, Carlos H Schenck
Jan 30, 2010·Parkinsonism & Related Disorders·Dennis W DicksonJ Eric Ahlskog
Apr 22, 2008·Parkinsonism & Related Disorders·Lucio MarinelliM Felice Ghilardi
Jul 31, 2007·Neurologic Clinics·Tanis J Ferman, Bradley F Boeve
Feb 1, 2013·Neuropathology and Applied Neurobiology·M E KalaitzakisR K B Pearce
Mar 12, 2004·Nihon rinsho. Japanese journal of clinical medicine·Tomoyoshi Kondo
Apr 3, 2012·The International Journal of Neuroscience·Anthony Barber, Khashayar Dashtipour
Jun 20, 2015·Journal of Movement Disorders·Eun Joo Chung, Sang Jin Kim
Jun 7, 2008·The Journal of International Medical Research·K KashiharaT Imamura
Dec 8, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lionel DahanGuy Chouvet
Nov 25, 2017·Nature Reviews. Neurology·Birgit HöglAleksandar Videnovic
Sep 6, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Giacomo ChiaroFederica Provini
Jul 11, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Sylvia M BoeschWerner Poewe
Nov 3, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Kenichi Kashihara, Takaki Imamura
May 23, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Birgit FrauscherBirgit Högl
Jan 5, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Cynthia L Comella
Feb 28, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Geert MayerKarin Stiasny-Kolster
Dec 6, 2012·Southern Medical Journal·Thomas FritschDavid S Geldmacher
Nov 7, 2020·Annals of Neurology·Cole D StangRodolfo Savica
May 15, 2021·Sleep Medicine Clinics·Ambra Stefani, Birgit Högl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.