Physiological and biochemical evidence for coordinate increases in muscarinic receptors and Gi during pacing-induced heart failure

Circulation
D E VatnerS F Vatner

Abstract

It is not clear whether the increase in the myocardial guanylyl nucleotide inhibitory protein (Gi), frequently observed in heart failure, is associated with any functional effects. Eight sham-operated dogs and 10 dogs were studied with pacing-induced heart failure (240 bpm for 4 to 7 weeks), characterized by reduced (P<.05) left ventricular dP/dt (from 2926+/-99 to 1303+/-126 mm Hg/s). The muscarinic agonist acetylcholine (10 micrograms/kg IV) in the presence of ganglionic blockade reduced left ventricular dP/dt more (P<.05) in heart failure (-23+/-2%) than before heart failure (-8+/-2%), despite lesser reductions in arterial pressure. Gi alpha2 was increased by 55% in heart failure. Dose-response curves for carbachol (10-8 to 10-3 mol/L) inhibition of isoproterenol-stimulated adenylyl cyclase demonstrated significantly greater (P<.05) inhibition in heart failure compared with sham-operated dogs. These changes were associated with a coordinate increase in muscarinic receptor density, determined by antagonist binding with 3H-quinuclidinyl benzilate, in heart failure (153+/-6.2 fmol/mg protein) compared with sham-operated dogs (124+/-7.4 fmol/mg protein). Agonist binding with carbachol also revealed an increase in total muscarini...Continue Reading

References

Nov 6, 1975·The New England Journal of Medicine·S F Vatner, E Braunwald
Jun 15, 1992·The American Journal of Cardiology·H DrexlerR Zelis
Jun 1, 1992·The Journal of Clinical Investigation·K KomamuraS F Vatner
Aug 1, 1989·Endocrine Reviews·G L Johnson, N Dhanasekaran
Apr 1, 1989·The American Journal of Physiology·L KaiserN B Olivier
Jul 1, 1988·The Journal of Clinical Investigation·A M FeldmanC Van Dop
Oct 22, 1988·Lancet·J NeumannP Kalmar
Dec 1, 1985·The Journal of Clinical Investigation·D E VatnerC J Homcy
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S M MumbyA G Gilman
Jun 1, 1988·The Journal of Clinical Investigation·D E VatnerC J Homcy
Apr 1, 1969·The American Journal of Physiology·M N Levy, H Zieske
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
Feb 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M DelhayeJ Christophe
May 1, 1994·The Journal of Clinical Investigation·Y IshikawaC J Homcy
Oct 1, 1993·The American Journal of Physiology·K KomamuraS F Vatner
Mar 1, 1993·The Journal of Clinical Investigation·K KiuchiD E Vatner

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Citations

Apr 27, 2005·Journal of Molecular and Cellular Cardiology·Luis E D GiménezEleonora Kurtenbach
Aug 12, 1999·European Journal of Pharmacology·C GiesslerO E Brodde
Nov 23, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Karl-Heinz KuckFrank Ruschitzka
Feb 22, 2001·Annual Review of Physiology·J D Molkentin, G W Dorn
Mar 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Motoki NiheiItsuo Kodama
May 18, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alejandro N MazzadiPhilippe Chevalier
Jun 4, 1999·Journal of Cardiovascular Electrophysiology·I C Van GelderH J Crijns
Sep 8, 2010·Heart Failure Reviews·Steve Bibevski, Mark E Dunlap
Mar 11, 2000·Journal of Receptor and Signal Transduction Research·N M Tepe, S B Liggett
Dec 12, 2012·Journal of Molecular and Cellular Cardiology·R I HussainK A Krobert
Sep 1, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S DheinO E Brodde
Mar 26, 2015·Current Opinion in Cardiology·Jonathan Grinstein, Daniel Burkhoff
Sep 23, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Kadri Murat GursesKudret Aytemir
Jun 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steve Bibevski, Mark E Dunlap
May 12, 2006·Journal of Cardiovascular Electrophysiology·Edward J F Danson, David J Paterson
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·X J DuE A Woodcock
Jun 28, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Mark E DunlapPaul Ernsberger
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M JainR M Mortensen
Feb 7, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Toshihide KashiharaMitsuhiko Yamada

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