Physiological and biochemical indices of neurohypophyseal function in the aging Fischer rat

Neuroendocrinology
W F SilvermanC D Sladek

Abstract

In order to resolve conflicting reports in the literature on the effect of aging on the hypothalamo neurohypophyseal system (HNS) in rats, multiple parameters associated with the HNS were evaluated in young (4 months), fully mature (14 months), and old (25 months) Fischer 344 rats under basal and stimulated conditions. The hypothalamic hormones oxytocin and vasopressin were compared in radioimmunoassay of serum, urine, brain and pituitary. Information on body weight, water intake, urine output, serum hematocrit and plasma osmolality was also obtained from the same subjects and analyzed together with these data. Finally, semi quantitative histofluorescence assessment of the noradrenergic innervation of the mediobasal hypothalamus from the same animals was performed to determine the extent of central afferent input to the HNS with advancing age. The circulating levels of vasopressin and oxytocin did not significantly differ in the three age groups under basal conditions. Serum vasopressin concentration was increased following water deprivation, and the increase was comparable in all age groups. Serum oxytocin was also increased following water deprivation in all groups, but the increase was greater in the 25-month-old rats relati...Continue Reading

Citations

Jan 15, 1991·Brain Research. Developmental Brain Research·W F Silverman, J R Sladek
Apr 19, 1996·Neuroscience Letters·L C SalandA Apodaca
Jan 1, 1994·Brain Research Bulletin·T J LauterioP F Aravich
Apr 13, 2000·The European Journal of Neuroscience·M E KeckI D Neumann
May 8, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert L ThunhorstAlan Kim Johnson
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Junyang JungYoungbuhm Huh
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert L Thunhorst, Alan Kim Johnson
Jul 1, 1995·The American Journal of Physiology·R Ghosh, C D Sladek

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