Physiological and metabolic functions of melatonin

Journal of Physiology and Biochemistry
J BarrenetxeJ A Martínez

Abstract

Melatonin is a lipophilic hormone, mainly produced and secreted at night by the pineal gland. Melatonin synthesis is under the control of postganglionic sympathetic fibers that innervates the pineal gland. Melatonin acts via high affinity G protein-coupled membrane receptors. To date, three different receptor subtypes have been identified in mammals: MT1 (Mel 1a) and MT2 (Mel 1b) and a putative binding site called MT3. The chronobiotic properties of the hormone for resynchronization of sleep and circadian rhythms disturbances has been demonstrated both in animal models or in clinical trials. Several other physiological effects of melatonin in different peripheral tissues have been described in the past years. In this way, it has been demonstrated that the hormone is involved in the regulation of seasonal reproduction, body weight and energy balance. This contribution has been focused to review some of the physiological functions of melatonin as well as the role of the hormone in the regulation of energy balance and its possible involvement in the development of obesity.

References

Jul 1, 1979·Physiological Reviews·B Rusak, I Zucker
Aug 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·B AlvarezJ D Parkes
May 1, 1990·Biological Psychiatry·E FerrariF Brambilla
Sep 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M L Dubocovich
Jan 1, 1987·Annals of the New York Academy of Sciences·N E RosenthalT A Wehr
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·T J Bartness, G N Wade
Apr 1, 1985·British Journal of Clinical Pharmacology·M AldhousJ Arendt
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·T EbisawaS M Reppert
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·S M ReppertJ F Gusella
Feb 1, 1995·Trends in Pharmacological Sciences·M L Dubocovich
Mar 1, 1994·Journal of Pineal Research·D Acuña-CastroviejoA Burgos
Feb 1, 1994·Neurochemistry International·P J MorganR Helliwell
Jan 1, 1994·Life Sciences·S Saarela, R J Reiter
Jan 1, 1996·Behavioural Brain Research·A J LewyR L Sack
Jul 1, 1996·Brain Research. Molecular Brain Research·C MazzucchelliB M Stankov
Oct 14, 1996·Molecular and Cellular Endocrinology·D G HazleriggP J Morgan
Dec 1, 1996·The International Journal of Eating Disorders·E I BylesjöL Wetterberg
Jan 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y SongM Silverman
Jan 1, 1997·Life Sciences·R ReiterA Muñoz-Hoyos
Dec 24, 1997·Clinical Neuropharmacology·P Delagrange, B Guardiola-Lemaitre
Dec 24, 1997·Journal of Biological Rhythms·J ArendtS Deacon
Apr 29, 1998·Annals of Medicine·T Kokkola, J T Laitinen
Feb 2, 1999·Neuroreport·W M Al-GhoulM L Dubocovich
Aug 14, 1999·Journal of Biological Rhythms·S BenloucifM L Dubocovich

❮ Previous
Next ❯

Citations

Aug 17, 2006·Journal of Physiology and Biochemistry·J F López-OlmedaF J Sánchez-Vázquez
Nov 25, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Ewa KulczykowskaRichard J Balment
May 18, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Isaac TúnezPedro Montilla
Jun 14, 2005·World Journal of Surgery·Edward RamZeev Dreznik
Jun 12, 2009·Drug Metabolism Reviews·Shu-Feng ZhouBalram Chowbay
Oct 26, 2011·Journal of Drug Targeting·Mohammad FazilJaved Ali
Apr 23, 2010·Expert Opinion on Investigational Drugs·Rüdiger Hardeland
Aug 10, 2010·Hormones and Behavior·Chiara Carla PiccinettiOliana Carnevali
Dec 17, 2008·Cancer Letters·Akila N Viswanathan, Eva S Schernhammer
Jan 10, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Scheila R SchaffazickSílvia S Guterres
Feb 7, 2009·Journal of Pineal Research·Sergio RegodónJuan A Rosado
Sep 16, 2006·Sleep Medicine Reviews·Phyllis C Zee, Prasanth Manthena
Nov 22, 2005·European Journal of Pharmacology·Lidiana Duarte de Almeida-PaulaRegina P Markus
Mar 3, 2015·Journal of Biomedical Materials Research. Part a·Sanjeev K PandeyPralay Maiti
May 31, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jing ZhuYung H Wong
Apr 26, 2016·Expert Review of Neurotherapeutics·Irene PaternitiSalvatore Cuzzocrea
Aug 13, 2009·The Journal of Black Psychology·Serge MadhereCharmaine D M Royal
Oct 9, 2007·Neuroreport·Min ZhangXiong-Li Yang
Jul 1, 2016·Perception·Marco Costa, Leonardo Bonetti
Jul 25, 2006·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·Nick Haslam
Sep 29, 2018·Mini Reviews in Medicinal Chemistry·Neha Sharma, Anurag
Mar 18, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lucia de Fatima Sobral Sampaio
Dec 24, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaochao MaFrank J Gonzalez
Dec 14, 2007·Organic & Biomolecular Chemistry·Simone LucariniGiovanni Piersanti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Bioscience : a Journal and Virtual Library
Margarita L DubocovichMonica I Masana
The New England Journal of Medicine
A Brzezinski
The International Journal of Biochemistry & Cell Biology
Rüdiger HardelandDaniel P Cardinali
Trends in Pharmacological Sciences
Jean A BoutinPhilippe Delagrange
© 2021 Meta ULC. All rights reserved