Physiological and molecular evidence of heat acclimation memory: a lesson from thermal responses and ischemic cross-tolerance in the heart

Physiological Genomics
Anna TetievskyMichal Horowitz

Abstract

Sporadic findings in humans suggest that reinduction of heat acclimation (AC) after its loss occurs markedly faster than that during the initial AC session. Animal studies substantiated that the underlying acclimatory processes are molecular. Here we test the hypothesis that faster reinduction of AC (ReAC) implicates "molecular memory." In vivo measurements of colonic temperature profiles during heat stress and ex vivo assessment of cross-tolerance to ischemia-reperfusion or anoxia insults in the heart demonstrated that ReAC only needs 2 days vs. the 30 days required for the initial development of AC. Stress gene profiling in the experimental groups highlighted clusters of transcriptionally activated genes (37%), which included heat shock protein (HSP) genes, antiapoptotic genes, and chromatin remodeling genes. Despite a return of the physiological phenotype to its preacclimation state, after a 1 mo deacclimation (DeAC) period, the gene transcripts did not resume their preacclimation levels, suggesting a dichotomy between genotype and phenotype in this system. Individual detection of hsp70 and hsf1 transcripts agreed with these findings. HSP72, HSF1/P-HSF1, and Bcl-xL protein profiles followed the observed dichotomized genomic ...Continue Reading

References

Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M R MontminyR H Goodman
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·M HorowitzR Mizrahi
Jul 1, 1997·The American Journal of Physiology·E J GriffithsH S Silverman
Jun 20, 1998·Progress in Brain Research·F K PierauP Haug
Aug 7, 1998·International Journal of Sports Medicine·K B Pandolf
Jan 8, 1999·Cell Stress & Chaperones·A Samali, S Orrenius
Feb 18, 1999·The Japanese Journal of Physiology·K HoriS Hori
May 8, 1999·The American Journal of Physiology·A MaloyanM Horowitz
Dec 5, 2000·Molecular Biology of the Cell·A P GaschP O Brown
Jun 19, 2002·Journal of Applied Physiology·Alina Maloyan, Michal Horowitz
Oct 23, 2002·Journal of Applied Physiology·Mirit EynanMichal Horowitz
Feb 12, 2004·Journal of Molecular and Cellular Cardiology·Kornelis W Patberg, Michael R Rosen
Nov 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew Y GraceyAndrew R Cossins
Aug 17, 2005·Current Opinion in Genetics & Development·Marco E Bianchi, Alessandra Agresti
Sep 16, 2005·Behavioural Brain Research·Daniela D PollakGert Lubec
Jun 30, 2006·Journal of Neurochemistry·Angel BarcoEric R Kandel
Jan 9, 2007·The Journal of Biological Chemistry·Yanping LiHua Lu
Jan 20, 2007·BMC Cardiovascular Disorders·Chandrashekhar D KamatMichael A Ihnat
Mar 8, 2007·The Journal of Physiological Sciences : JPS·Megumi MaruyamaOsamu Shido

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Citations

Apr 25, 2012·European Journal of Applied Physiology·Yung-Kai HuangHung-Che Chiang
Aug 30, 2011·Cell Stress & Chaperones·Jordan Thomas Silver, Earl G Noble
Apr 21, 2010·Medicine and Science in Sports and Exercise·Michal Horowitz, Einat Kodesh
May 18, 2011·Nitric Oxide : Biology and Chemistry·Sandra ImbrognoAlfonsina Gattuso
Nov 12, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gali UmscheifEsther Shohami
Mar 6, 2010·Annals of the New York Academy of Sciences·Michal Horowitz, Halla Assadi
Nov 12, 2014·Annual Review of Animal Biosciences·Robert J Collier, Kifle G Gebremedhin
Mar 10, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rivka Alexander-ShaniMichal Horowitz
Nov 13, 2010·Circulation Research·Jody GroenendykMarek Michalak
Sep 4, 2010·Journal of Applied Physiology·Anna Tetievsky, Michal Horowitz
Jun 12, 2013·Journal of Basic and Clinical Physiology and Pharmacology·Laxmi Prabha SinghShashi Bala Singh
Oct 17, 2015·Journal of Applied Physiology·Michal Horowitz
Jun 5, 2020·Science Advances·Colin RaymondRadley M Horton
Aug 15, 2017·Frontiers in Physiology·Michal Horowitz
Mar 25, 2019·Temperature : Multidisciplinary Biomedical Journal·J Luke PryorRiana R Pryor
Jul 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Brett R ElyChristopher T Minson
Nov 13, 2017·Sports Medicine·Hein A M DaanenJulien D Périard
Feb 9, 2021·Temperature : Multidisciplinary Biomedical Journal·Lisa KlousNicola Gerrett
Aug 18, 2012·The Journal of Experimental Biology·Dao H Ho, Warren W Burggren

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