Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells

Virology
Jean K Millet, Gary R Whittaker

Abstract

During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) protein, a class I viral fusion protein that has several unique features. Coronavirus entry is unusual in that it is often biphasic in nature, and can occur at or near the cell surface or in late endosomes. Recent advances in structural, biochemical and molecular biology of the coronavirus S protein has shed light on the intricacies of coronavirus entry, in particular the molecular triggers of coronavirus S-mediated membrane fusion. Furthermore, characterization of the coronavirus fusion peptide (FP), the segment of the fusion protein that inserts to a target lipid bilayer during membrane fusion, has revealed its particular attributes which imparts some of the unusual properties of the S protein, such as Ca2+-dependency. These unusual characteristics can explain at least in part the biphasic nature of coronavirus entry. In this review, using severe acute respiratory syndrome coronavirus (SARS-CoV) as model virus, we give an overview of advances in research on the coronavirus fusion peptide with an emphasis on its role and properties within t...Continue Reading

Citations

Jul 7, 2020·International Journal of Molecular Medicine·Felician StancioiuAristidis Tsatsakis
Aug 26, 2020·Cellular and Molecular Neurobiology·Walter J LukiwJames M Hill
Sep 5, 2020·Pharmaceuticals·Aleksandra HecelMagdalena Rowińska-Żyrek
Jan 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Angela SteinauerAlanna Schepartz
Jun 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ayal B GussowEugene V Koonin
Aug 29, 2020·Cells·Muhammad Aslam, Yury Ladilov
Jul 10, 2020·Reviews in Endocrine & Metabolic Disorders·Mónica MarazuelaManuel Puig-Domingo
Aug 14, 2020·Human Vaccines & Immunotherapeutics·Mohamad Hesam ShahrajabianQi Cheng
May 12, 2020·Frontiers in Microbiology·Longping V TseRalph S Baric
Oct 22, 2020·Science·James L DalyYohei Yamauchi
Oct 15, 2020·Environmental Science and Pollution Research International·Tatiana Borisova, Serhiy Komisarenko
Nov 3, 2020·Cell Biochemistry and Function·Davide FerrariGiovanni Lombardi
Nov 10, 2020·Endocrine·Luigi di FilippoAndrea Giustina
Dec 8, 2020·Clinical Science·Fiona J WarnerChandana B Herath
Nov 27, 2020·Psychiatry and Clinical Neurosciences·Júlio César TolentinoSergio Luis Schmidt
Oct 28, 2020·The Protein Journal·Shanzay SuhailSanchita Hati
Dec 21, 2020·Stem Cell Research·Shi XiaojieQiang Min
Feb 11, 2021·Colloids and Surfaces. A, Physicochemical and Engineering Aspects·Kazushige Yokoyama, Akane Ichiki
Feb 3, 2021·International Journal of Molecular Sciences·Nicholas A Wong, Milton H Saier
Feb 16, 2021·Frontiers in Immunology·Edwin Estefan Reza-ZaldívarAlejandro Arturo Canales-Aguirre
Nov 17, 2020·Frontiers in Immunology·Taylon Felipe SilvaMilena Menegazzo Miranda-Sapla
Nov 26, 2020·American Journal of Physiology. Endocrinology and Metabolism·Narasimhan KothandaramanMelvin Khee Shing Leow
Dec 11, 2020·Journal of Pathogens·James P ChambersBernard P Arulanandam
Jan 8, 2021·Electrolyte & Blood Pressure : E & BP·Jeong-Hoon LimJang-Hee Cho
Feb 2, 2021·Colloid and Interface Science Communications·Kazushige Yokoyama, Akane Ichiki
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gema Lizbeth Ramírez-SalinasJazmín García-Machorro
Nov 23, 2020·Biochemical and Biophysical Research Communications·Cody B JacksonHyeryun Choe
Mar 6, 2021·International Journal of Biological Macromolecules·Pedro F N SouzaRaquel C Montenegro
Feb 27, 2021·Briefings in Bioinformatics·Jim Warwicker
Mar 4, 2021·Nature Medicine·Christoph MuusUNKNOWN Human Cell Atlas Lung Biological Network

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
electron spin resonance
nuclear magnetic resonance
NMR
electron
differential scanning calorimetry
circular dichroism
isothermal titration calorimetry

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
R Ieki
Yi chuan xue bao = Acta genetica Sinica
Wen-Guang ZhangHuan-Min Zhou
© 2021 Meta ULC. All rights reserved