Physiological and morphological characteristics of progressive disruption of the canine gastric mucosal barrier

Digestive Diseases and Sciences
D G KellyJ F Schlegel

Abstract

The investigation had two major goals: to define the progression of physiological changes associated with disruption of the gastric mucosal barrier to sodium and hydrogen and to identify the morphological correlates of the physiological alterations. Fluxes of ions and water were determined before and after treatment of oxyntic mucosa with graded concentrations of butyric acid using dogs with gastric pouches. Three phases of barrier disruption were characterized: I, acceleration of normal Na+/H+ exchange; II, neutralization of H+; III, exudation of interstitial fluid. Parallel studies assessed morphological damage associated with these phases. In Phase I, cellular bulging into the lumen and dilation of intercellular spaces were evident. Some cellular erosion and extreme intercellular dilation were prominent in Phase II. Phase III was represented by necrotic changes and desquamation. It is concluded that disruption of transport mechanisms occurs sequentially and is closely correlated with morphological signs of progressive damage.

References

Nov 1, 1985·Digestive Diseases and Sciences·G L Kauffman
Oct 1, 1996·Digestive Diseases and Sciences·T MuraiN Sato
May 1, 1983·Digestive Diseases and Sciences·M T DaytonJ H Steinbach
Dec 11, 1992·The Journal of Surgical Research·T R SullivanD T Dempsey
Jul 1, 1983·The Journal of Surgical Research·K D LillemoeL F Johnson
Sep 1, 1990·The Journal of Surgical Research·L BushnellJ McGreevy
Jun 4, 1999·Journal of Gastroenterology and Hepatology·T OsadaS Watanabe

Citations

Dec 30, 1975·Annals of the New York Academy of Sciences·W S Rehm, S S Sanders
Aug 1, 1978·Canadian Journal of Physiology and Pharmacology·D G Kelly, C F CODE
Oct 1, 1973·The American Journal of Digestive Diseases·C J Pfeiffer, J Weibel
Jan 1, 1972·Scientific American·H W Davenport
Feb 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·N W WeisbrodtA R Cooke
Jul 1, 1973·The American Journal of Physiology·U L VenturaC F CODE
Sep 1, 1970·The American Journal of Digestive Diseases·V P DinosoS H Lorber
Dec 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·H W Davenport
Dec 1, 1968·Acta Physiologica Scandinavica·G Flemström, B Frenning
Mar 1, 1957·Journal of Applied Physiology·R J REITEMEIERA L ORVIS
Jan 1, 1960·Perspectives in Biology and Medicine·C F CODE
Apr 1, 1963·The Journal of Physiology·C F CODEJ F SCHOLER
Nov 20, 1939·The Journal of General Physiology·T Teorell

Related Concepts

Chloride Ion Level
Mucositis
Potassium
Structure of Pyloric Gland
Mesothelium
Electron Microscopy
Sodium
Potentials, Event-Related
Atropine Sulfate Anhydrous
Butyric Acids

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