Physiological and oncogenic roles of the PRL phosphatases

The FEBS Journal
S HardyMichel L Tremblay

Abstract

The human Phosphatase of Regenerative Liver (PRL) family comprises three members (PRL-1, -2, -3; gene name PTP4A1, PTP4A2, PTP4A3) that are highly expressed in a majority of cancers. This review summarizes our current understanding of PRL biology, including an overview of their evolutionary relationships and the regulatory mechanisms controlling their expression. We provide an updated view on our current knowledge on the PRL functions in solid tumors, hematological cancer, and normal physiology, particularly emphasizing on the use of in vivo mouse models. We also highlight a novel relationship positioning PRL as a central node controlling magnesium homeostasis through an association with the CNNM proteins, which are involved in magnesium transport.

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Citations

Aug 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Qinglin LiZhong-Yin Zhang
Feb 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Serge HardyMichel L Tremblay
Jul 4, 2020·Journal of Clinical Pathology·Gabriela Deisi Moyano CrespoJorge Mukdsi
Dec 5, 2019·Cell & Bioscience·Xinyue DuZhaojun Wang
Oct 12, 2019·The Journal of Pharmacology and Experimental Therapeutics·John S LazoElizabeth R Sharlow
Oct 25, 2020·Communications Biology·Mathilde PouletAndreas Bikfalvi
Nov 13, 2020·Journal of Surgical Oncology·Premila D LeiphrakpamChandrakanth Are
Sep 8, 2019·Cell Calcium·Valentina Trapani, Federica I Wolf
Jan 12, 2021·Frontiers in Cell and Developmental Biology·Patricia Castro-SánchezPedro Roda-Navarro
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pegah AbdollahiMagne Børset
Jun 6, 2021·Cellular and Molecular Life Sciences : CMLS·Yevgen ZolotarovJeroen H F de Baaij
Jun 16, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Teresa RubioMaja Köhn
Apr 29, 2020·ACS Central Science·Maja Köhn

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