PMID: 3320551Jan 1, 1987Paper

Physiological and pathological effects of steroids on the function of the adrenal cortex

Journal of Steroid Biochemistry
P J Hornsby

Abstract

The adrenal cortex is the site of the synthesis of steroid hormones such as the glucocorticoid cortisol and the mineralocorticoid aldosterone. The pathway of biosynthesis of these steroids from cholesterol involves a sequence of transformations using cytochrome P-450 enzymes which varies within the adrenal cortex as a result of the differential localization of enzymes within the zones. The hypothesis presented here is that as a result of the arrangement of the vasculature in the adrenal gland, high concentrations of steroids may be expected to accumulate and may have autoregulating effects. These may include the following: (1) the normal morphological and functional zonation of the adrenal cortex may be regulated by gradients of steroids in the adrenal cortex; (2) destruction of cytochrome P-450 enzymes on interaction with certain steroids which act as pseudosubstrates may form part of the pathogenesis of some steroidogenic enzyme deficiencies. Under normal conditions, the individual cytochrome P-450s are not rate-limiting for steroidogenesis. Under some pathological conditions, individual cytochrome P-450 enzyme activities may become rate-limiting, with consequent overproduction of precursor steroids, leading to mineralocortic...Continue Reading

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Citations

Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·P H ProvencherA Bélanger
Aug 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·A EndohY Igarashi
Apr 3, 2001·European Journal of Clinical Investigation·D l'Allemand, A Biason-Lauber
May 11, 2012·The Journal of Endocrinology·Peter J Hornsby
Oct 7, 2015·Journal of Toxicologic Pathology·Akira Inomata, Hironobu Sasano
Jul 10, 2012·Journal of Theoretical Biology·Meital Weiss, Amotz Zahavi
Jul 6, 2016·Frontiers in Neuroscience·Gavin P Vinson
Jul 7, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·D SorannoW Drucker
Sep 1, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·D GillisA Rösler
Oct 1, 1991·Clinical Cardiology·S P KarasM B Gravanis
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·G GennarelliC Berne
Mar 3, 2021·Cell and Tissue Research·Felix FriedrichHolger S Willenberg
Jun 1, 1992·The American Journal of Physiology·P H ProvencherA Bélanger
Oct 19, 2002·Journal of Reproductive Immunology·Dale Buchanan Hales

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