PMID: 167913Aug 22, 1975

Physiological and pharmacological evidence for a serotonergic projection to the hippocampus

Brain Research
M Segal

Abstract

Rat hippocampal pyramidal cells were studied for their response to serotonin applied iontophoretically and to stimulation of the midbrain raphe nuclei. Ninety-two percent of the cells studied were inhibited by serotonin. Fourty-eight percent of the cells responded by inhibition to dorsal and median raphe stimulation. The inhibitory response to raphe stimulation was absent when the rats were pretreated with p-chlorophenylalanine (PCPA), a serotonin synthesis inhibitor; PCPA effects were alleviated by 5-HTP or 5-HT administration. The response to raphe stimulation was blocked by emthysergide and cyproheptadine. The responses to raphe stimulation were potentiated by chlorimipramine, a serotonin reuptake blocker. These data satisfy several of the criteria required to identify serotonin as the inhibitory neurotransmitter for the raphe-hippocampal pathway

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Citations

Oct 1, 1972·Electroencephalography and Clinical Neurophysiology·H M Geller, D J Woodward
Feb 1, 1974·Journal of Comparative and Physiological Psychology·P D Mabry, B A Campbell
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Mar 1, 1970·European Journal of Pharmacology·I Geller, K Blum
Jan 1, 1967·Experimental Brain Research·E EidelbergL Deza

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