PMID: 167913Aug 22, 1975

Physiological and pharmacological evidence for a serotonergic projection to the hippocampus

Brain Research
M Segal


Rat hippocampal pyramidal cells were studied for their response to serotonin applied iontophoretically and to stimulation of the midbrain raphe nuclei. Ninety-two percent of the cells studied were inhibited by serotonin. Fourty-eight percent of the cells responded by inhibition to dorsal and median raphe stimulation. The inhibitory response to raphe stimulation was absent when the rats were pretreated with p-chlorophenylalanine (PCPA), a serotonin synthesis inhibitor; PCPA effects were alleviated by 5-HTP or 5-HT administration. The response to raphe stimulation was blocked by emthysergide and cyproheptadine. The responses to raphe stimulation were potentiated by chlorimipramine, a serotonin reuptake blocker. These data satisfy several of the criteria required to identify serotonin as the inhibitory neurotransmitter for the raphe-hippocampal pathway


Apr 11, 1979·Psychopharmacology·L N Fleisher, S D Glick
Jan 1, 1984·Neuroscience and Behavioral Physiology·E I ChumasovE A Gromova
Jan 1, 1982·Neuroscience and Behavioral Physiology·V A Markevich, L L Voronin
May 1, 1984·Neuroscience and Behavioral Physiology·E S Brazhnik, O V Vinogradova
Jan 1, 1997·Journal of Neural Transmission·G FerraroV La Grutta
Aug 31, 2013·Experimental Brain Research·María Esther Olvera-CortésMiguel Angel López-Vázquez
Nov 19, 1976·Brain Research·A E Snow, A Horita
Nov 18, 1985·Brain Research·T T SoncrantS I Rapoport
Apr 1, 1991·Electroencephalography and Clinical Neurophysiology·M SabatinoV La Grutta
Sep 15, 1978·European Journal of Pharmacology·J Davies, P Tongroach
Oct 15, 1978·European Journal of Pharmacology·H J Haigler
Oct 14, 1986·European Journal of Pharmacology·A Basse-Tomusk, G V Rebec
Oct 1, 1978·Physiology & Behavior·F G Graeff, N G Silveira Filho
Nov 1, 1991·Physiology & Behavior·L GlinC Gottesmann
Jul 1, 1993·Physiology & Behavior·M L Marván, C M Contreras
Mar 1, 1979·Pharmacology, Biochemistry, and Behavior·R F Smith
Feb 1, 1980·Pharmacology, Biochemistry, and Behavior·W WetzelH Matthies
Sep 1, 1981·Pharmacology, Biochemistry, and Behavior·E A CavalheiroC J Campos
Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
Jan 1, 1992·Pharmacology & Therapeutics·J A Pratt
Jul 9, 1987·Neuroscience Letters·M SabatinoV La Grutta
Nov 22, 1988·Neuroscience Letters·G Richter-Levin, M Segal


Oct 1, 1972·Electroencephalography and Clinical Neurophysiology·H M Geller, D J Woodward
Feb 1, 1974·Journal of Comparative and Physiological Psychology·P D Mabry, B A Campbell
Mar 1, 1974·Pharmacology, Biochemistry, and Behavior·L D Fechter
Sep 27, 1974·Brain Research·E C Azmitia, B S McEwen
Aug 30, 1973·Brain Research·D Paupardin-Tritsch, H M Gerschenfeld
Jun 20, 1974·Brain Research·Y S SheuF E Bloom
Jul 1, 1974·The Journal of Comparative Neurology·L C ConradD W Pfaff
Aug 30, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Seiger, L Olson
Mar 1, 1970·European Journal of Pharmacology·I Geller, K Blum
Jan 1, 1967·Experimental Brain Research·E EidelbergL Deza

Related Concepts

Clomipramine Maleate (1: 1)
Reaction Time
Synaptic Transmission
Neural Pathways
Reticular Formation
Fenclonine, (D)-Isomer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.