Physiological Approach to Sodium Supplementation in Preterm Infants

American Journal of Perinatology
David E SegarJeffrey L Segar

Abstract

To implement and evaluate a clinical practice algorithm to identify preterm infants with sodium deficiency and guide sodium supplementation based on urine sodium concentrations. Urine sodium concentration was measured in infants born at 260/7 to 296/7 weeks' gestation at 2-week intervals. Sodium supplementation was based on the urine sodium algorithm. Growth and respiratory outcomes in this cohort were compared with a matched cohort cared for in our neonatal intensive care unit prior to algorithm implementation (2014-2015 cohort). Data were compared for 50 infants in the 2014-2015 cohort and 40 infants in the 2016 cohort. Urine sodium concentration met criteria for supplementation in 75% of the 2016 cohort infants within the first 4 weeks after birth. Average daily sodium intake was greater in the 2016 cohort compared with the 2014-2015 cohort (p < 0.05). Caloric, protein, and total fluid intakes were similar between cohorts. The change in weight Z-score between 2 and 8 weeks of age was significantly greater in the 2016 versus 2014-2015 cohort (0.32 ± 0.05 vs. -0.01 ± 0.08; p < 0.01). No impact on respiratory status at 28 days of age or 36 weeks of postmenstrual age was identified. Institution of a clinical practice algorithm t...Continue Reading

Associated Clinical Trials

Citations

Jan 16, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey L SegarJustin L Grobe
Oct 9, 2019·Journal of Neonatal-perinatal Medicine·J L Segar
Jan 14, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey L SegarJustin L Grobe
May 21, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey L SegarJustin L Grobe

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