PMID: 9524454Apr 1, 1997Paper

Physiological approaches to the control of oral biofilms

Advances in Dental Research
P D Marsh, D J Bradshaw

Abstract

Evidence that physiological strategies may be potential routes for oral biofilm control has come from (i) observations of the variations in the intra-oral distribution of members of the resident oral microflora, (ii) changes in plaque composition in health and disease, and (iii) data from laboratory model systems. Key physiological factors that were identified as significant in modulating the microflora included the local pH, redox potential (Eh), and nutrient availability. Increases in mutans streptococci and lactobacilli occur at sites with caries; growth of these species is selectively enhanced at low pH. In contrast, periodontal diseases are associated with plaque accumulation, followed by an inflammatory host response. The increases in Gram-negative, proteolytic, and obligately anaerobic bacteria reflect a low redox potential and a change in nutrient status due to the increased flow of gingival crevicular fluid (GCF). Consequently, physiological strategies for oral biofilm control should focus on reducing the frequency of low pH in plaque by (i) inhibiting acid production, (ii) using sugar substitutes, and (iii) promoting alkali generation from arginine or urea supplements. Similarly, strategies to make the pocket environm...Continue Reading

References

Jun 1, 1992·FEMS Microbiology Reviews·H J BusscherH C van der Mei
Jan 1, 1991·Archives of Oral Biology·F M EggertM Goldner
Oct 1, 1990·Australian Dental Journal·A H Rogers
Jun 1, 1989·Oral Microbiology and Immunology·G H Bowden, I R Hamilton
May 1, 1989·Journal of Dental Research·R J Gibbons
Jan 1, 1987·Caries Research·G M Best, A T Brown
Dec 1, 1987·Oral Microbiology and Immunology·A H RogersA L Pfennig
Dec 1, 1986·Microbiological Reviews·W J Loesche
Jan 1, 1971·Annual Review of Microbiology·M Alexander
Oct 1, 1981·Journal of Periodontology·J JensenC Bloomquist
Jan 1, 1982·Archives of Oral Biology·T F McNamaraL M Golub
Sep 1, 1995·Journal of Dental Research·N Guha-ChowdhuryE I Pearce
Jun 1, 1994·Archives of Oral Biology·C H SissonsT W Cutress
Apr 1, 1994·Journal of Bacteriology·J W CostertonG James
Mar 1, 1993·Journal of Dental Research·D Grenier
Jun 1, 1993·Journal of Bacteriology·P E Kolenbrander, J London
Jan 1, 1995·Annual Review of Microbiology·J W CostertonH M Lappin-Scott
Feb 1, 1996·The Journal of Applied Bacteriology·D J BradshawD Cummins

❮ Previous
Next ❯

Citations

Dec 12, 2001·International Journal of Antimicrobial Agents·S DoronH Zvia
Apr 12, 2001·Journal of Applied Microbiology·R J HodgsonC Allison
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Nikolaos S SoukosJ Max Goodson
Mar 7, 2003·Applied and Environmental Microbiology·Thomas ThurnheerBernhard Guggenheim
Oct 29, 2004·Journal of Oral Science·Yoshiaki NomuraNobuhiro Hanada
Jun 25, 2013·Lasers in Medical Science·N C AraújoM E M Gerbi
Apr 29, 2015·Bioscience of Microbiota, Food and Health·Ayumi ShimadaMasanori Sugiyama
May 19, 2007·Journal of Endodontics·Luis E Chavez de Paz, Luis Chávez de Paz
Aug 18, 2004·Journal of Clinical Periodontology·Thomas BeiklerThomas F Flemmig
Apr 20, 2011·Periodontology 2000·Lijian Jin
Jun 5, 2013·Australian Dental Journal·L J Walsh, A M Brostek
Jun 16, 2011·Journal of Applied Microbiology·P RogerC Béal
Feb 19, 2016·Journal of Dental Research, Dental Clinics, Dental Prospects·Aldo Del Carpio-PerochenaSamuel Lucas Fernandes
Oct 6, 2000·Annual Review of Microbiology·P E Kolenbrander
Jan 31, 2007·Brazilian Dental Journal·Laurylene César de Souza VasconcelosMaria Helena Pereira Peixoto
Apr 17, 2007·Journal of Photochemistry and Photobiology. B, Biology·Y L QinZ G Zhang
Mar 13, 1998·Journal of Dental Research·R A Burne
Aug 8, 2009·Advances in Dental Research·J M Bob ten Cate
Apr 1, 1997·Advances in Dental Research·C H Sissons
Aug 28, 2004·Periodontology 2000·Tatsuji Nishihara, Takeyoshi Koseki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Related Papers

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Mustafa K KartalZeki Alkan
© 2022 Meta ULC. All rights reserved