Physiological aspects and clinical sequelae of energy deficiency and hypoestrogenism in exercising women

Human Reproduction Update
Mary Jane De Souza, Nancy I Williams

Abstract

Amenorrhoea associated with reduced caloric intake and strenuous exercise leads to hypoestrogenism and is associated with clinical manifestations that include disordered eating, stress fractures, osteoporosis, and, as recently reported, a potential increase in the risk of premature cardiovascular disease. Disordered eating, menstrual irregularities and bone loss comprise the clinical condition known as the 'female athlete triad'. The aetiology of the triad is linked to a high prevalence of disordered eating and cognitive restraint. This results in inadequate caloric intake for high exercise energy expenditures that leads to energy deficiency. This in turn stimulates compensatory mechanisms, such as weight loss or energy conservation, subsequently causing a central suppression of reproductive function and concomitant hypoestrogenism. Because the aetiology of menstrual disturbances and the female athlete triad is causally linked to energy deficiency, there is no justification for fears that exercise itself is unhealthy for women. However, improved detection, monitoring, and treatment of all components of the triad in exercising women should be emphasized. This paper critically reviews the physiological aspects and clinical sequel...Continue Reading

References

Jul 1, 1979·Obstetrics and Gynecology·E DaleA L Wilhite
Apr 1, 1976·Fertility and Sterility·G S Jones
Apr 1, 1992·Clinical Science·J E CompstonS Kreitzman
Jan 11, 1992·Reproductive Toxicology·J S KesnerE F Krieg
Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·I Z BeitinsB A Bullen
Jul 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J L CameronW H Kaye
Oct 1, 1990·The Medical Journal of Australia·R CarbonM G Yeates
Nov 1, 1990·The New England Journal of Medicine·J C PriorA E Burgess
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S M Ott
Jan 26, 1990·JAMA : the Journal of the American Medical Association·B L DrinkwaterC H Chesnut
May 1, 1990·Journal of Applied Physiology·A BroocksD Jeschke
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·S Lamon-FavaE J Schaefer
Feb 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A B LoucksS S Yen
Jul 1, 1988·Fertility and Sterility·M J McNeely, M R Soules
Oct 1, 1987·Human Reproduction·J Balasch, J A Vanrell
Jan 1, 1987·Psychotherapy and Psychosomatics·D M GarnerM P Olmsted
Sep 1, 1987·Circulation·D Steinberg
May 1, 1986·American Journal of Obstetrics and Gynecology·P T Ellison, C Lager
Jul 18, 1986·JAMA : the Journal of the American Medical Association·B L DrinkwaterC H Chesnut
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J D VeldhuisA D Rogol
May 23, 1985·The New England Journal of Medicine·B A BullenJ W McArthur
Sep 1, 1973·American Journal of Obstetrics and Gynecology·F PetterssonS J Nillius
Jan 1, 1974·The Journal of Clinical Endocrinology and Metabolism·B M Sherman, S G Korenman
Feb 1, 1970·The Journal of Clinical Endocrinology and Metabolism·C A StrottM B Lipsett
Dec 1, 1983·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T HataM Kitao
Feb 3, 1984·JAMA : the Journal of the American Medical Association·C E CannR B Jaffe
Aug 2, 1984·The New England Journal of Medicine·B L DrinkwaterM B Southworth
Nov 1, 1980·The Journal of Clinical Endocrinology and Metabolism·M P Warren
Aug 15, 1982·American Journal of Obstetrics and Gynecology·C F SanbornW W Wagner
Nov 15, 1981·American Journal of Obstetrics and Gynecology·B SchwartzR W Rebar
Jul 3, 1980·The New England Journal of Medicine·R E FrischL Vincent
Aug 1, 1995·The Journal of Clinical Investigation·S K GrinspoonA Klibanski
Aug 1, 1994·Journal of the American College of Cardiology·D S CelermajerJ E Deanfield
Dec 1, 1993·Human Reproduction·P T EllisonM T O'Rourke
Jan 1, 1994·The American Journal of Clinical Nutrition·S I BarrY M Vigna
Jun 1, 1993·Journal of Applied Physiology·O M Rutherford

❮ Previous
Next ❯

Citations

Apr 25, 2013·Current Reviews in Musculoskeletal Medicine·Michelle T BarrackJenna C Gibbs
Dec 6, 2007·Journal of Sports Sciences·Melinda M ManoreUNKNOWN International Association of Athletics Federations
Jun 7, 2008·Human Reproduction Update·Elizabeth H RuderMarlene B Goldman
Nov 16, 2007·Current Sports Medicine Reports·Constance Marie Lebrun
Nov 12, 2005·Current Sports Medicine Reports·Elizabeth A Joy, Darren Campbell
Sep 6, 2005·Current Opinion in Obstetrics & Gynecology·Linnea R Goodman, Michelle P Warren
Dec 23, 2006·British Journal of Sports Medicine·M J De SouzaM P Warren
Aug 29, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Karsten KoehlerWilhelm Schaenzer
May 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jennifer L ReedNancy I Williams
Oct 11, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Rand Randall MartinsMaria das Graças Almeida
Aug 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Charles E MatthewsRegina G Ziegler
Oct 3, 2007·Medicine and Science in Sports and Exercise·Aurelia NattivUNKNOWN American College of Sports Medicine
Dec 19, 2012·Medicine and Science in Sports and Exercise·Jenna C GibbsMary Jane De Souza
Aug 21, 2013·Medicine and Science in Sports and Exercise·Jenna C GibbsMary Jane De Souza
Oct 24, 2007·Sports Medicine·David L NicholsEve V Essery
Jun 18, 2009·Sports Medicine·Maarten H MoenTheodorus C De Winter
Jun 22, 2011·Sports Medicine·Gaele DucherMary Jane De Souza
Feb 25, 2014·British Journal of Sports Medicine·Anna MelinJorunn Sundgot-Borgen
Jan 9, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J D VescoviM J De Souza
Jul 12, 2014·Current Sports Medicine Reports·Elizabeth JoyJorunn Sundgot Borgen
Sep 10, 2014·Journal of Endocrinological Investigation·B MeczekalskiM Maciejewska-Jeske
Mar 27, 2013·The Physician and Sportsmedicine·James PegrumJulian Flynn
Jan 6, 2010·The Physician and Sportsmedicine·Karen HindSean Carroll
Oct 1, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Agnieszka Podfigurna-StopaBlazej Meczekalski
Jul 9, 2010·Clinics in Sports Medicine·Stacy L Lynch, Anne Z Hoch
May 30, 2008·Physiology & Behavior·Jason D VescoviMary Jane De Souza
Apr 10, 2007·Journal of Pediatric and Adolescent Gynecology·William W K To, Margaret W N Wong
Mar 21, 2007·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jennifer L CarlsonBonnie Halpern-Felsher
Dec 23, 2006·Appetite·Mary Jane De SouzaNancy I Williams
Mar 10, 2016·Hormone Molecular Biology and Clinical Investigation·Heather C M AllawayMary Jane De Souza
Jun 25, 2008·Annals of the New York Academy of Sciences·Michelle P Warren, Abigail T Chua
Sep 16, 2010·Annals of the New York Academy of Sciences·Samuel A Pauli, Sarah L Berga
Jul 12, 2005·Physical Medicine and Rehabilitation Clinics of North America·Heidi Prather, Deyvani Hunt

❮ Previous
Next ❯

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