Physiological basis of muscle functional MRI: predictions using a computer model

Journal of Applied Physiology
Bruce M Damon, John C Gore

Abstract

Muscle functional MRI (mfMRI) has been proposed as a tool for noninvasively measuring the metabolic and hemodynamic responses to muscle activation, but its theoretical basis remains unclear. One challenge is that it is difficult to isolate individually those variables affecting the magnitude and temporal pattern of the mfMRI response. Therefore, the purpose of this study was to develop a computer model of how physiological factors altered during exercise affect the mfMRI signal intensity time course and then predict the contributions made by individual factors. A model muscle containing 39,204 fibers was defined. The fiber-type composition and neural activation strategies were designed to represent isometric contractions of the human anterior tibialis muscle, for which published mfMRI data exist. Sustained isometric contractions at 25 and 40% maximum voluntary contraction were modeled, as were the vascular (capillary recruitment, blood oxygen extraction) and metabolic (lactate accumulation, phosphocreatine hydrolysis, pH) responses. The effects on the transverse relaxation of MRI signal were estimated, and the mfMRI signal intensity time course was measured from simulated images. The model data agreed well qualitatively with pu...Continue Reading

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Citations

Dec 18, 2010·Journal of Applied Physiology·Christopher P ElderBruce M Damon
Mar 9, 2012·Anesthesiology Research and Practice·Danai Udomtecha
Aug 21, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Erin K EnglundFelix W Wehrli
Sep 6, 2011·The Journal of Orthopaedic and Sports Physical Therapy·Barbara CagnieLieven A Danneels
Feb 20, 2018·The Journal of Physiology·Andreas BossArend Heerschap
Nov 1, 2006·NMR in Biomedicine·Jeanine J PrompersKlaas Nicolay
Nov 1, 2006·NMR in Biomedicine·P G CarlierY Fromes
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bruce M DamonDrew A Lansdown
Dec 20, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elizabeth A LouieBruce M Damon
Sep 2, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christopher P ElderBruce M Damon
Jul 29, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Otto A SanchezBruce M Damon
Apr 13, 2007·Physical Therapy·Richard L Segal
Feb 16, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin MeyerspeerEwald Moser
Apr 23, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kiril SchewzowAlbrecht Ingo Schmid

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