PMID: 9444496Jan 1, 1997Paper

Physiological, biochemical and subjective parameters in anxiety patients with panic disorder during stress exposure as compared with healthy controls

European Archives of Psychiatry and Clinical Neuroscience
T HoehnM Albus

Abstract

Physiological (heart rate, blood pressure, electrodermal activity), biochemical (epinephrine, norepinephrine, cortisol) and subjective parameters (self-rating score) of 33 patients with panic disorder (diagnoses according to DSM-III-R) before, during and after stress exposure were compared with those of healthy controls. As stressors a video containing frightening scenes (FS), mental arithmetic (MA), a video documenting a patient suffering from a panic attack (PA) and an improvised speech (IS) were applied. We found significantly higher baseline levels of electrodermal activity (EDA) and norepinephrine (NE) secretion and a subsequent further increase during stress exposure in panic disorder patients as compared with normal controls. The most potent stressors during the trial proved to be mental arithmetics and improvised speech, which was evident in both groups. The situation panic attack video appeared to be a "panic disorder patient-specific" stressor; here we noticed the most pronounced reactions in the patient group. Panic disorder patients had significantly higher self-rating scores of the parameters panicky feelings, anxiety and nervousness at the beginning and throughout the investigation. We conclude that panic disorder...Continue Reading

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Citations

Dec 7, 2007·Psychopharmacology·Christian Grillon
Jun 18, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alexandre C B V ParenteFrederico G Graeff
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Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael DavisChristian Grillon
Jan 15, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Katja PetrowskiClemens Kirschbaum
Dec 2, 2015·Journal of Anxiety Disorders·Katja PetrowskiJana Strahler
Feb 16, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Sigrun DoberenzSunyoung Kim
Jun 12, 2010·Journal of Psychiatric Research·Sigrun DoberenzSunyoung Kim
Oct 15, 2009·Journal of Strength and Conditioning Research·Marta Del SalVilberto Stocchi
Jan 1, 2014·Psychiatry and Clinical Neurosciences·Ken-ichi YamamotoMitsunobu Yoshii
Jun 25, 2017·Applied Psychophysiology and Biofeedback·Mascha van 't WoutM Tracie Shea
Aug 8, 2021·International Journal of Environmental Research and Public Health·Kyung-O KimDeborah Gritzmacher

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