Physiological Characteristics of Lactobacillus casei Strains and Their Alleviation Effects against Inflammatory Bowel Disease.

Journal of Microbiology and Biotechnology
Yang LiuWei Chen

Abstract

Lactobacillus casei, one of the most widely used probiotics, has been reported to alleviate multiple diseases. However, the effects of this species on intestinal diseases are strain-specific. Here, we aimed to screen L. casei strains with inflammatory bowel disease (IBD)-alleviating effects based on in vitro physiological characteristics. Therefore, the physiological characteristics of 29 L. casei strains were determined, including gastrointestinal transit tolerance, oligosaccharide fermentation, HT-29 cell adhesion, generation time, exopolysaccharide production, acetic acid production, and conjugated linoleic acid synthesis. The effects of five candidate strains on mice with induced colitis were also evaluated. The results showed that among all tested L. casei strains, only Lactobacillus casei M2S01 effectively relieved colitis. This strain recovered body weight, restored disease activity index score, and promoted anti-inflammatory cytokine expression. Gut microbiota sequencing showed that L. casei M2S01 restored a healthy gut microbiome composition. The western blotting showed that the alleviating effects of L. casei M2S01 on IBD were related to the inhibition of the NF-κB pathway. A good gastrointestinal tolerance ability ma...Continue Reading

References

Oct 1, 1987·The American Journal of Physiology·P S KamathS F Phillips
Oct 1, 1995·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·A Hague, C Paraskeva
Jun 1, 2000·Applied and Environmental Microbiology·H Kaplan, R W Hutkins
Feb 7, 2001·The American Journal of Clinical Nutrition·C DunneJ K Collins
Dec 4, 2003·Research in Microbiology·Richard TallonMaria C Urdaci
Jan 9, 2004·Applied and Environmental Microbiology·D SgourasA Mentis
Dec 20, 2005·Diseases of the Colon and Rectum·Neriman SengülFuat Atalay
Dec 31, 2005·Molecular and Cellular Biology·Jamie E HobergMarty W Mayo
Dec 16, 2006·Digestive Diseases and Sciences·Jessica WinklerErin Symonds
Apr 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sinéad C CorrCormac G M Gahan
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tarun BansalArul Jayaraman
Dec 8, 2009·Bioscience, Biotechnology, and Biochemistry·Yuko NagataToshiharu Gomyo
Jan 22, 2010·The Journal of Nutrition·Nicholas P EvansJosep Bassaganya-Riera
May 28, 2010·The ISME Journal·Maria L MarcoMichiel Kleerebezem
Apr 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara E JonesKatherine L Knight
Feb 11, 2015·The EMBO Journal·Yaíma L LightfootMansour Mohamadzadeh
Mar 26, 2015·Travel Medicine and Infectious Disease·Chunhong XieDaorong Chen
Apr 17, 2015·Critical Reviews in Food Science and Nutrition·Ashok Kumar YadavVirender Kumar Batish
Dec 10, 2015·Nature·Caroline A LindemansAlan M Hanash
Dec 1, 2012·Probiotics and Antimicrobial Proteins·Claudio Hidalgo-CantabranaPatricia Ruas-Madiedo
Mar 15, 2016·Frontiers in Microbiology·Alistair D S WalshamStephanie Schüller
Apr 3, 2016·British Journal of Clinical Pharmacology·Robyn BruenOrina Belton
Apr 12, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ran LiLinShu Liu
Dec 22, 2016·Nature·Michael Eisenstein

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