PMID: 8460095Mar 1, 1993Paper

Physiological characteristics of spontaneously developed diabetes in male WBN/Kob rat and prevention of development of diabetes by chronic oral administration of synthetic trypsin inhibitor (FOY-305)

Pancreas
I ShimodaT Toyota

Abstract

The male WBN/Kob rats spontaneously develop diabetes mellitus with age. In this study, we examined how glucose tolerance, potency of insulin release, and histology of the pancreas were changed with age in this model. Furthermore, we examined the effect of FOY-305, a synthetic trypsin inhibitor, on this model. Male WBN/Kob rats were divided into two groups: one group fed on standard pellet diet (STD group) and the other on pellet containing 0.1% FOY-305 (FOY group) for 56 weeks after age 4 weeks. Oral glucose (2 g/kg) tolerance test, histology of the pancreas, and glucose (8.3 mM)- and arginine (10 mM)-stimulated insulin release from the isolated perfused pancreas were examined at 8, 20, 40, and 60 weeks of age in both groups. Pancreatic insulin content was examined at 60 weeks. In the STD group, impairment of glucose tolerance and destruction and fibrosis of pancreatic tissues progressed with age. Glucose-stimulated insulin release was remarkably reduced with age, while arginine-stimulated insulin release was preserved. By contrast, in the FOY group, development of glucose intolerance was delayed and the pancreas showed fewer pathologic changes compared with the STD group. Insulin releases in response to both glucose and argini...Continue Reading

Citations

Nov 1, 1995·Digestive Diseases and Sciences·M GotoH Nawata
Jul 19, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·R GrafD Bimmler
Sep 30, 1999·Gastroenterology Clinics of North America·S Y Kang, V L Go
Nov 22, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Marwa E AbdelmageedHatem A Salem
Jan 1, 2021·Environmental Toxicology and Pharmacology·Marwa E AbdelmageedHatem A Salem
Jul 19, 2011·Journal of Agricultural and Food Chemistry·Kohsuke AdachiHiroki Saeki

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