Physiological characterization of Taxol-induced large-fiber sensory neuropathy in the rat

Annals of Neurology
K D ClifferP S DiStefano

Abstract

The cancer chemotherapeutic agent Taxol (paclitaxel) causes a dose-related peripheral neuropathy in humans. We produced a dose-dependent large-fiber sensory neuropathy, without detrimental effects on general health, in mature rats by using two intravenous injections 3 days apart. Tests of other dosing schedules demonstrated the dependence of the severity of the neuropathy and of animal health on both the dose and the frequency of dosing. Pathologically, severe axonal degeneration and hypomyelination were observed in sections of dorsal roots, whereas ventral roots remained intact. Electrophysiologically, H-wave amplitudes in the hindlimb and amplitudes of predominantly sensory compound nerve action potentials in the tail were reduced. These effects persisted for at least 4 months after treatment. Motor amplitudes were not affected, but both motor and sensory conduction velocities decreased. The ability of rats to remain balanced on a narrow beam was impaired, indicating proprioceptive deficits. Muscle strength, measured by hindlimb and forelimb grip strength, and heat nociception, measured by tail-flick and hindlimb withdrawal tests, were not affected by Taxol. This model of Taxol-induced neuropathy in mature rats, with minimal ...Continue Reading

References

Aug 1, 1978·The American Journal of Medicine·N E Madias, J T Harrington
Dec 1, 1991·Toxicology and Applied Pharmacology·F P HamersW H Gispen
Jan 1, 1991·Annals of Neurology·S C ApfelJ A Kessler
Aug 1, 1986·Journal of Neurocytology·M Röyttä, C S Raine
Mar 1, 1989·Neurology·R B LiptonH H Schaumburg
Apr 1, 1988·European Journal of Cancer & Clinical Oncology·R Gerritsen van der HoopW H Gispen
Aug 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P H WiernikJ P Dutcher
Jun 1, 1987·Experimental Neurology·J D Schmelzer, P A Low
May 1, 1987·Neuroscience·T SittirachaC Bell
Aug 1, 1973·Electroencephalography and Clinical Neurophysiology·T Miyoshi, I Goto
Sep 1, 1974·Journal of the Neurological Sciences·A K Sharma, P K Thomas
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M van GervenC J Vecht
Oct 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E K RowinskyR C Donehower
Nov 1, 1994·Journal of the Neurological Sciences·R Gerritsen van der HoopF G Jennekens
Jul 1, 1994·Archives of Neurology·Z SahenkJ R Mendell
Jun 1, 1994·Journal of Neurotrauma·A F GermanòF Tomasello
Mar 16, 1993·European Journal of Pharmacology·F P HamersW H Gispen
Jul 1, 1996·Neurology·R J FreilichL M DeAngelis

❮ Previous
Next ❯

Citations

Mar 31, 2000·Journal of Neuroscience Research·M P ter LaakW H Gispen
Oct 15, 1998·Muscle & Nerve·K D ClifferP S DiStefano
May 25, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Debra L BartonCharles L Loprinzi
Jan 1, 2003·Current Neurology and Neuroscience Reports·Louis H Weimer
May 3, 2013·Neurotoxicity Research·Krystyna M WozniakBarbara S Slusher
Mar 15, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ahmet Höke
May 26, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Elke PersohnGuido Cavaletti
Aug 28, 2013·Neuropharmacology·Erica Gornstein, Thomas L Schwarz
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nicolas AuthierAlain Eschalier
Jul 2, 2003·Toxicology and Applied Pharmacology·G BárdosP Literáti-Nagy
Nov 26, 2003·Neurotoxicology·Nicolas AuthierFrançois Coudore
Sep 11, 2002·Trends in Neurosciences·Michael P Coleman, V Hugh Perry
Aug 26, 2003·Advanced Drug Delivery Reviews·Lili X Wang, Zaijie Jim Wang
Sep 16, 2003·Neurotoxicology and Teratology·Jacques P J MaurissenKenneth E Stebbins
Dec 14, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rudolf KirchmairDouglas W Losordo
Mar 13, 2014·ILAR Journal·Ahmet Höke, Mitali Ray
Oct 30, 2001·Experimental Neurology·J R TonraP S DiStefano
May 1, 2010·Cellular and Molecular Life Sciences : CMLS·Laurence MeyerAyikoe Guy Mensah-Nyagan
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R C Polomano, G J Bennett
Jan 26, 2008·Journal of Neuropathology and Experimental Neurology·Yu-Lin HsiehSung-Tsang Hsieh
Nov 26, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Takehiro KawashiriRyozo Oishi
May 22, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C E Urch, A H Dickenson
Apr 2, 2009·Journal of the Peripheral Nervous System : JPNS·Ilaria RoglioRoberto C Melcangi
Dec 25, 2009·Fundamental & Clinical Pharmacology·Amteshwar Singh JaggiNirmal Singh
Mar 15, 2011·The European Journal of Neuroscience·Gary J BennettChiang Siau
Mar 27, 2012·Neuropathology and Applied Neurobiology·V AnneseM T Herrero
Jul 16, 2010·Journal of the Peripheral Nervous System : JPNS·Herbert H SchaumburgJoseph Arezzo
Jul 26, 2008·Brain Research·Juan P CataPatrick M Dougherty
Jun 20, 2015·Pain Management·Jessica A Boyette-DavisPatrick M Dougherty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.