PMID: 7527477Jan 1, 1994Paper

Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum

Life Sciences
D PozoJ M Guerrero

Abstract

In the present paper we show the inhibitory effect of melatonin on rat cerebellar nitric oxide synthase (NOS) activity. NO production was monitored by the stoichiometric conversion of L-arginine to L-citrulline. The inhibitory effect of melatonin was dose-dependent, with an IC50 value of about 0.1 mM. However, a significant inhibition of enzyme activity (> 22%) was observed at 1 nM melatonin which is in the range of the physiological serum concentration of the hormone at night. The inhibitory effect of melatonin was observed exclusively in the presence of Ca++. Results suggest a new and important role of the pineal hormone melatonin on central nervous system processes, i.e., by modulating NO production.

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Citations

Nov 4, 2000·Journal of Biomedical Science·R J ReiterE Gitto
Jun 22, 2006·Neurotoxicity Research·M F BealT Archer
Apr 25, 2012·Archives of Toxicology·In-Chul LeeJong-Choon Kim
Sep 11, 2007·Bioscience Reports·Deepa S MaharajSanty Daya
Aug 30, 2001·European Journal of Pharmacology·S Cuzzocrea, R J Reiter
Jul 23, 1997·European Journal of Pharmacology·F NavaA P Caputi
Jan 7, 1999·European Journal of Pharmacology·G CostantinoA P Caputi
Jun 5, 2002·Mechanisms of Ageing and Development·Russel J ReiterSusanne Burkhardt
Oct 14, 1998·Progress in Neurobiology·R J Reiter
Jun 19, 2001·Experimental Gerontology·Y Touitou
May 30, 1998·British Journal of Pharmacology·G G GearyD N Krause
Jan 1, 1995·Journal of Pineal Research·R J ReiterD Acuña-Castroviejo
May 1, 1995·Journal of Pineal Research·C M CagnoliH Manev
Sep 1, 1995·Journal of Pineal Research·D Acuña-CastroviejoR Montes
Nov 1, 1995·Journal of Pineal Research·R M SainzA Menendez-Pelaez
Jan 1, 1996·Journal of Pineal Research·R J ReiterR J Clayton
Mar 1, 1996·Journal of Pineal Research·G J Maestroni
May 1, 1996·Journal of Pineal Research·A M Filadelfi, A M Castrucci
May 1, 1996·Journal of Pineal Research·I BettahiJ M Guerrero
Sep 1, 1996·Journal of Pineal Research·A Molina-CarballoD Acuña-Castroviejo
May 1, 1997·Journal of Pineal Research·A Panzer, M Viljoen
Dec 10, 1997·Journal of Pineal Research·C LopesM Mariano
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Aug 7, 1998·Journal of Pineal Research·S CuzzocreaA P Caputi
Aug 7, 1998·Journal of Pineal Research·C MésengeM Plotkine
Oct 1, 1998·Journal of Pineal Research·P L MontillaE S Cabrera

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