Physiological consequences of selective suppression of synaptic transmission in developing cerebral cortical networks in vitro: differential effects on intrinsically generated bioelectric discharges in a living 'model' system for slow-wave sleep activity

Neuroscience and Biobehavioral Reviews
Michael Alan CornerJ van Pelt

Abstract

Within the context of an updated thorough review of the literature concerning activity-dependent cerebro-cortical development, a survey is made of recent experiments which utilize spontaneous spike-trains as the dependent variable in rodent neocortex cultures when synaptic transmission is interfered with during early ontogeny. Emphasis is placed on the complexity of homeostatic adaptations to reduced as well as intensified firing. Two kinds of adaptation are distinguished: (i) rapid recovery (within several hours) towards baseline levels despite sustained blockade of excitatory synaptic transmission, and (ii) the generation of essentially normal firing patterns in cultures assayed in control medium following development in the presence of excitatory receptor blockers. The former category of homeostatic responses is strongly dependent on the type of preparation, with isolated organotypic explants showing greatly limited plasticity in comparison with co-cultures of matching contralateral pieces of cortical tissue. In such co-cultures, compensatory excitatory drive manifests itself even when all three known types of ionotropic glutamate receptors are chronically blocked, and is then mediated by (muscarinic) cholinergic mechanisms ...Continue Reading

References

Mar 1, 1990·Trends in Neurosciences·B W Connors, M J Gutnick
Aug 1, 1991·Electroencephalography and Clinical Neurophysiology·F Lopes da Silva
Sep 1, 1991·Trends in Neurosciences·J E Cook
Dec 1, 1991·Southern Medical Journal·G Brock, H S Nelson
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R E BakerD Bingmann
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R E BakerD Bingmann
Jul 1, 1990·Brain Research. Developmental Brain Research·H J Luhmann, D A Prince
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M A Corner, M Mirmiran
Jul 1, 1987·Electroencephalography and Clinical Neurophysiology·M J O'BrienH F Prechtl
Oct 1, 1989·The Journal of Comparative Neurology·U B SchambraJ M Lauder
Nov 30, 1988·Mechanisms of Ageing and Development·J J O'LearyH M Hallgren
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H O Reiter, M P Stryker
Oct 1, 1969·Journal of Theoretical Biology·B C Goodwin, M H Cohen
Nov 1, 1972·The Journal of the Royal College of General Practitioners·R J Pinsent
Apr 15, 1973·Experientia·M A Corner, A P Richter
Mar 1, 1966·Experimental Neurology·P KellawayM Proler
Dec 14, 1981·Life Sciences·P Lavie, D F Kripke
Aug 1, 1995·Current Opinion in Neurobiology·G Buzsáki, J J Chrobak
Jan 1, 1995·Brain Research Bulletin·M MirmiranN P Bos
Jun 1, 1994·Trends in Neurosciences·A Ruiz i Altaba
Jul 1, 1995·Behavioural Brain Research·M Mirmiran
Aug 1, 1994·Current Opinion in Neurobiology·J Bolz
Nov 1, 1994·Journal of Reproduction and Fertility·S P BrinskoJ E Ellington
Nov 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G J RamakersG J Boer
Jan 1, 1994·The European Journal of Neuroscience·M Götz, J Bolz
Jul 15, 1994·Brain Research. Developmental Brain Research·E C Burgard, J J Hablitz

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Citations

Apr 7, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Michel J A M van Putten, Maurice H P M van Putten
Sep 18, 2010·The European Journal of Neuroscience·Jyh-Jang SunHeiko J Luhmann
Jul 9, 2014·Brain Research·Francis E Lotrich
Mar 1, 2012·PloS One·Vicente Botella-SolerMichel Le Van Quyen
Jun 28, 2014·Current Opinion in Neurobiology·Christiane Linster, Alfredo Fontanini
Aug 20, 2010·Journal of Neural Engineering·M GandolfoL Berdondini
Apr 21, 2018·Scientific Reports·Sohrab Saberi-MoghadamMehdi Tafti
Nov 5, 2019·Frontiers in Neuroscience·Sasha D'AmbrosioSergio Garbarino

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