Physiological consequences of the passage of peptides across the blood-brain barrier
Peptides given peripherally have been shown to affect the central nervous system (CNS). Peptides are also capable of crossing the blood-brain barrier (BBB). It is unclear, however, whether such crossing underlies the ability of peptides to affect the CNS. We review specific examples in which a peptide must cross the BBB to produce its effect. The effect elicited by passage often duplicates the effect elicited at peripheral sites of action. Other examples, however, are reviewed in which peptides have opposite effects after central and peripheral administration. Such paradoxical effects suggest that passage of peptides may be involved in feedback or counter-regulatory loops.
Leucine modulates peptide transport system-1 across the blood-brain barrier at the stereospecific site within the central nervous system
Lack of saturable transport across the blood-brain barrier in either direction for beta-amyloid1-28 (Alzheimer's disease protein)
Differentiated hemodynamic responses to central versus peripheral administration of corticotropin-releasing factor in conscious rats
Transport of desglycinamide-arginine vasopressin across the blood-brain barrier in rats as evaluated by the unit impulse response methodology
Inhibition of the brain to blood transport system for enkephalins and Tyr-MIF-1 in mice addicted or genetically predisposed to drinking ethanol
Intracerebroventricular administration of bombesin inhibits biliary and gastric secretion in the rat
Pharmacological evidence of a central effect of naltrexone, morphine, and beta-endorphin and a peripheral effect of met- and leu-enkephalin on retention of an inhibitory response in mice
Cardiovascular effect of intravenously administered thyrotropin-releasing hormone and its concentration in push-pull perfusion of the fourth ventricle in conscious and pentobarbital-anesthetized rats
Sleep-wave activity of a delta sleep-inducing peptide analog correlates with its penetrance of the blood-brain barrier
Hypermotility induced by vasoactive intestinal peptide in the rat: its reciprocal action to cholecystokinin octapeptide
Paradoxical elevation of growth hormone by intraventricular somatostatin: possible ultrashort-loop feedback
Comparison of the effects of TRH and D-Ala2-metenkephalinamide on hippocampal electrical activity and behavior in the unanesthetized rat
Effects of TRH and PS-24 on colonic temperature and motor activity of rats: possible role of dopamine
Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity
Substance P decreases extracellular concentrations of acetylcholine in neostriatum and nucleus accumbens in vivo: possible relevance for the central processing of reward and aversion
Effects of chronic substance P treatment and intracranial fetal grafts on learning after hippocampal kainic acid lesions
Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays
Effects of an acidic fibroblast growth factor fragment analog on learning and memory and on medial septum cholinergic neurons in senescence-accelerated mice
Perinatal treatment of rats with opiates affects the development of the blood-brain barrier transport system PTS-1
Modulation of somatostatin receptors, somatostatin content and Gi proteins by substance P in the rat frontoparietal cortex and hippocampus
Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis.
Transport of CRH from mouse brain directly affects peripheral production of beta-endorphin by the spleen
Subacute melamine exposure disrupts task-based hippocampal information flow via inhibiting the subunits 2 and 3 of AMPA glutamate receptors expression.
Blood Brain Barrier Chips
The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.
Blood Brain Barrier
The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.