PMID: 8275277Oct 1, 1993Paper

Physiological consequences of the passage of peptides across the blood-brain barrier

Reviews in the Neurosciences
W A Banks, A J Kastin


Peptides given peripherally have been shown to affect the central nervous system (CNS). Peptides are also capable of crossing the blood-brain barrier (BBB). It is unclear, however, whether such crossing underlies the ability of peptides to affect the CNS. We review specific examples in which a peptide must cross the BBB to produce its effect. The effect elicited by passage often duplicates the effect elicited at peripheral sites of action. Other examples, however, are reviewed in which peptides have opposite effects after central and peripheral administration. Such paradoxical effects suggest that passage of peptides may be involved in feedback or counter-regulatory loops.


May 1, 1977·British Journal of Pharmacology·K P BhargavaY P Srivastava
Jul 30, 1979·Life Sciences·A J KastinD H Coy
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·A J KastinW A Banks
Nov 1, 1991·Pharmaceutical Research·W A BanksC M Barrera
Apr 1, 1991·Brain : a Journal of Neurology·S A SparrN Venna
Apr 1, 1990·The International Journal of Neuroscience·B D JankovićJ Veljić
Apr 24, 1990·Regulatory Peptides·R J SheldonL A Fisher
Sep 1, 1985·Brain Research Bulletin·W A Banks, A J Kastin
Jan 1, 1987·Annals of the New York Academy of Sciences·B D Janković, D Marić
Sep 14, 1987·Life Sciences·W A Banks, A J Kastin
Dec 1, 1987·Brain Research Bulletin·C M BarreraW A Banks
Jun 1, 1987·Immunology Letters·B D Janković, D Marić
Jan 1, 1987·Journal of Neuroscience Research·W A BanksE A Michals
Jan 1, 1985·Psychoneuroendocrinology·W A Banks, A J Kastin
Mar 1, 1985·Peptides·M Holdeman, J M Lipton
Sep 16, 1983·European Journal of Pharmacology·J M Van ReeD De Wied
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·H Goldman, S Murphy
Jan 1, 1981·Peptides·G P SmithJ Thornton
Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
Mar 1, 1982·Physiology & Behavior·P J KulkoskyG P Smith

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May 1, 1995·Pharmacology, Biochemistry, and Behavior·W A BanksJ B Jaspan
Jan 23, 1995·Behavioural Brain Research·J P Huston, R U Hasenöhrl
Jan 1, 1995·Peptides·W A Banks, A J Kastin
Jul 20, 2002·Journal of Psychiatric Research·P EikelenboomW van Tilburg
May 1, 1997·Neuroscience and Biobehavioral Reviews·B SakićJ A Denburg
Sep 1, 1994·Behavioral and Neural Biology·R U HasenöhrlJ P Huston
Jan 30, 2002·Peptides·Anita L FreedSusan M Lunte
May 7, 2003·Peptides·Dilek Dogrukol-AkMuzaffer Tuncel
Sep 2, 2003·Peptides·Zhongjie SunMelvin Fregly
Nov 25, 2000·Metabolism: Clinical and Experimental·A J KastinL Hackler
Feb 13, 2016·Scientific Reports·Noriko Suzuki-KemuriyamaMasayoshi Shichiri
Jul 24, 2012·Pharmacology & Therapeutics·William A BanksMichelle A Erickson
May 20, 2008·Regulatory Peptides·William A Banks
Nov 17, 2007·Peptides·Tulin O PriceWilliam A Banks
Apr 20, 2004·European Journal of Pharmacology·William A Banks
Aug 7, 2013·Brain, Behavior, and Immunity·Pramod K MishraWeihong Pan
Nov 2, 2006·Expert Opinion on Drug Delivery·William A Banks
Aug 1, 2006·Neurologic Clinics·Joachim RothThomas Hübschle
Feb 13, 2003·The Journal of Biological Chemistry·Céline AdessiClaudio Soto
May 28, 2019·Nature Reviews. Endocrinology·William A Banks
Jan 22, 1998·The American Journal of Physiology·J M MartinsA J Kastin

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