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Physiological disposition and metabolism of 5-(2',4'-difluorophenyl)salicyclic acid, a new salicylate

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

D J ToccoC V Perrier

PMID: 1220

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Abstract

5-(2'4'-Difluorophenyl) [carboxy-14C]salicyclic acid (MK-647) was quickly and completely absorbed in rats, dogs, and man. Peak levels of plasma radioactivity occurred in 1-2 hr after oral administration. The dose was 10 mg/kg in rats and dogs, and 50 or 500 mg in man. Most of the drug i...read more

Mentioned in this Paper

Oral Cavity
Ethers
Glucagon Tolerance Test
Glucuronides
Glucose Tolerance Test
Human urine
Canis familiaris
Salicylic Acids
Salicylate Measurement
Salicylate
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  • Physiological disposition and metabolism of 5-(2',4'-difluorophenyl)salicyclic acid, a new salicylate

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    D J ToccoC V Perrier

    PMID: 1220

    DOI:

    Abstract

    5-(2'4'-Difluorophenyl) [carboxy-14C]salicyclic acid (MK-647) was quickly and completely absorbed in rats, dogs, and man. Peak levels of plasma radioactivity occurred in 1-2 hr after oral administration. The dose was 10 mg/kg in rats and dogs, and 50 or 500 mg in man. Most of the drug i...read more

    Mentioned in this Paper

    Oral Cavity
    Ethers
    Glucagon Tolerance Test
    Glucuronides
    Glucose Tolerance Test

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