Physiological doses of secretin do not stimulate acute insulin release

The Journal of Clinical Endocrinology and Metabolism
R G Brodows, W Y Chey


To study the effect of physiological increments in plasma secretin concentrations on basal and glucose-stimulated insulin release, bolus iv glucose injections (5 g) were given to normal weight volunteers (less than 108% ideal BW) before, during, and 30 min after a secretin infusion at a rate of 0.125 U/kg.h, raising mean plasma immunoreactive secretin to 35.5 +/- 8.3 pg/ml. Acute insulin responses to glucose were unaffected during or after the secretin infusion. Furthermore, when plasma glucose was elevated to postprandial levels (128--165 mg/dl), a similar secretin infusion also failed to alter acute insulin responses. In addition, no changes in basal glucose or insulin levels were found when endogenous secretin concentrations were increased by intraduodenal acid infusion. Thus, increases in plasma secretin to concentrations seen in the postprandial state fail to alter acute insulin secretion. It is unlikely that secretin plays any role in the intestinal stimulation of insulin secretion.


Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
Dec 1, 1986·Acta Physiologica Scandinavica·B Ahrén, I Lundquist
May 27, 2010·Journal of Endocrinological Investigation·D H St-Pierre, F Broglio
Dec 19, 2012·General and Comparative Endocrinology·Revathi Sekar, Billy K C Chow
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Eugenio Bertelli, Moïse Bendayan
Feb 5, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ida M ModvigJens J Holst
Feb 1, 1986·The American Journal of Physiology·H KofodC J Hedeskov

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