Physiological effects of an antimycotic azasterol on cultures of Saccharomyces cerevisiae.

Antimicrobial Agents and Chemotherapy
P R HaysL W Parks

Abstract

The yeast Saccharomyces cerevisiae has been studied during cultivation with a naturally occurring antimycotic azasterol. At very low concentrations (1.0 to 10.0 ng/ml), where growth retardation is not observed, an unusual sterol, ergosta-8,14-dien-3beta-ol, accumulates in high concentrations. Upon removal of the azasterol from the culture, the 8,14-diene is converted to ergosterol. Much smaller amounts of another 8,14-sterol, but with an additional unsaturation, have also been observed. Total sterol accumulation is higher in cultures containing subinhibitory levels of the antimycotic agent than the amounts of normal sterol accumulation in control cultures. With between 10 and 100 ng of azasterol per ml a transitory cessation of growth is observed from which the culture is able to recover. At much higher concentrations growth inhibition and even cell lysis results. Competitive inhibition of sterol 24(28)methylene reductase is demonstrated.

References

Mar 1, 1977·Journal of Bacteriology·W D Neal, L W Parks
Jul 1, 1976·Canadian Journal of Biochemistry·L AvruchA C Oehlschlager
Dec 1, 1976·Journal of Bacteriology·R B BaileyL W Parks
Nov 1, 1975·Journal of Bacteriology·R B Bailey, L W Parks
Jan 1, 1971·The Biochemical Journal·I A WatkinsonM Akhtar
Dec 1, 1974·The Journal of Antibiotics·J W ChamberlinJ L Occolowitz
Nov 1, 1969·The Biochemical Journal·M AkhtarI A Watkinson

❮ Previous
Next ❯

Citations

Oct 1, 1978·Lipids·L W ParksS Hough
Nov 1, 1980·Antimicrobial Agents and Chemotherapy·R J Rodriguez, L W Parks
Aug 1, 1981·Antimicrobial Agents and Chemotherapy·R J Rodriguez, L W Parks
Jun 1, 1985·Antimicrobial Agents and Chemotherapy·D P KasbekarE R Katz
Jan 1, 1978·CRC Critical Reviews in Microbiology·L W Parks
Dec 22, 1978·Biochimica Et Biophysica Acta·C K Bottema, L W Parks
Nov 1, 1978·Journal of Bacteriology·F R Taylor, L W Parks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.