PMID: 11315178Apr 21, 2001Paper

Physiological effects of FMRFamide-related peptides and classical transmitters on dispersed muscle fibres of the turbellarian, Procerodes littoralis

Parasitology
C G MoneypennyA G Maule

Abstract

The physiological effects of selected classical transmitters and FMRFamide-related peptides (FaRPs) on dispersed muscle fibres from the marine turbellarian, Procerodes littoralis have been examined. Confocal scanning laser microscopy coupled with fluorescein isothiocyanate (FITC) or tetramethylrhodamine (TRITC)-labelled phalloidin revealed a highly developed body wall muscle system with circular, longitudinal and diagonal layers of muscle fibres. Dispersed muscle fibres contracted when depolarized by exposure to extracellular media with elevated K+ (15-100 mM) in a concentration-dependent manner, with a maximal response of 87% achieved at > or = 75 mM. 5-Hydroxytryptamine (5-HT) induced concentration-dependent muscle contraction between 0.01 and 1000 microM, with 10 microM producing a near maximal contraction response of 75%. Acetylcholine (ACh) had less pronounced excitatory effects (0.01-1000 microM), inducing contraction of only 32% of the fibres at 100 microM. The flatworm FMRFamide-related peptides (FaRPs), GYIRFamide, YIRFamide and GNFFRFamide each had concentration-dependent myocontractile effects, indicating the occurrence of at least 1 FaRP receptor on P. littoralis muscle fibres. At 10 microM peptide, GNFFRFamide indu...Continue Reading

Citations

Mar 30, 2006·Parasitology·P RibeiroN Patocka
Mar 30, 2006·Parasitology·P McVeighT A Day
Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Apr 14, 2009·International Journal for Parasitology·Paul McVeighAaron G Maule
Mar 17, 2007·International Journal for Parasitology·Hanan H OmarTim A Day
Sep 15, 2004·Trends in Parasitology·Angela MousleyAaron G Maule
Apr 28, 2004·International Journal for Parasitology·Angela MousleyAaron G Maule
Sep 28, 2005·International Journal for Parasitology·Angela MousleyNikki J Marks
May 11, 2011·International Journal for Parasitology·Paul McVeighAaron G Maule
Apr 18, 2015·Arthropod Structure & Development·Jana WillkommenStanislav N Gorb
Oct 27, 2015·Genetics and Molecular Biology·Sigmer Y QuirogaFederico D Brown
Jul 28, 2018·Helminthologia·N B TereninaS O Movsesyan

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