Physiological effects of human muscle-derived stem cell implantation on urethral smooth muscle function.

International Urogynecology Journal and Pelvic Floor Dysfunction
Akira FurutaMichael B Chancellor

Abstract

The physiological effects of human muscle-derived stem cell (MDSC) implantation on urethral smooth muscle function were investigated in pudendal nerve-transected nude rats with human MDSC (TM) or saline (TS) injection into the proximal urethra compared with sham-operated, saline-injected nude rats (SS). Leak point pressure (LPP) before and after hexamethonium application, which can block autonomic efferent nerves, and proximal urethral contractile responses to carbachol and phenylephrine in muscle strip study were examined 6 weeks after the implantation. There was no significant difference between the LPPs in SS and TM. Following hexamethonium application, the LPP in TM was, however, significantly decreased compared with SS. The contractile responses to phenylephrine, but not to carbachol, in TM were significantly increased compared with SS and TS. These results suggest that the restorative effects of MDSCs are mediated by autonomic nerves and that increased sensitivity of alpha(1)-adrenoceptors may be related to restore the deficient urethral function.

References

Dec 1, 1987·British Journal of Urology·S C HarrisonP T Doyle
Sep 10, 1998·The Journal of Cell Biology·Z QuJ Huard
Apr 2, 1999·Science·M F PittengerD R Marshak
May 22, 2002·The Journal of Cell Biology·Zhuqing Qu-PetersenJohnny Huard
Feb 26, 2003·International Urogynecology Journal and Pelvic Floor Dysfunction·J Y LeeM B Chancellor
Sep 1, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Deirdre A ConwayTracy W Cannon
Feb 9, 2006·British Journal of Pharmacology·William C de Groat
Apr 26, 2006·Neurourology and Urodynamics·Chih-Wei PengChen-Li Cheng
Jun 21, 2007·Neurourology and Urodynamics·Akira FurutaMichael B Chancellor
Jul 10, 2007·Muscle & Nerve·Yong Tae KimMichael B Chancellor
Oct 6, 2007·Expert Opinion on Biological Therapy·Akira FurutaMichael B Chancellor

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Citations

Jun 15, 2011·Cell and Tissue Research·Neill J Turner, Stephen F Badylak
Aug 16, 2011·Current Urology Reports·Charuspong DissarananMargot S Damaser
Nov 30, 2011·Stem Cells and Development·Ching-Shwun Lin, Tom F Lue
Mar 30, 2011·International Urogynecology Journal·Akira FurutaNaoki Yoshimura
Nov 23, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Y XuZ X Lin
Apr 16, 2015·Korean journal of urology·Amjad AlwaalTom F Lue
Dec 9, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Yuka Tsukagoshi OkabeMomokazu Gotoh

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