Abstract
Controlled, repeat-measures study. To determine if functional electrical stimulation (FES) can affect bone atrophy in early spinal cord injury (SCI), and the safety, tolerance and feasibility of this modality in bone loss remediation. Spinal Injuries Units, Royal Adelaide Hospital and Hampstead Rehabilitation Centre, South Australia. Patients with acute SCI (ASIA A-D) were allocated to FES (n=23, 28+/-9 years, C4-T10, 13 Tetra) and control groups (CON, n=10, 31+/-11 years, C5-T12, four Tetra). The intervention group received discontinuous FES to lower limb muscles (15 min sessions to each leg twice daily, over a 5-day week, for 5 months). Dual energy X-ray absorptiometry (DEXA) measured total body bone mineral density (tbBMD), hip, spine BMD and fat mass (FM) within 3 weeks, and 3 and 6 months postinjury. FES and CON groups' tbBMD differed significantly at 3 months postinjury (P<0.01), but not thereafter. Other DEXA measures (hip, spine BMD, FM) did not differ between groups at any time. No adverse events were identified. Electrically stimulated muscle activation was elicited, and tetanic effects were reproducible; however, there were no convincing trends to suggest that FES can play a clinically relevant role in osteoporosis p...Continue Reading
References
Dec 1, 1992·American Journal of Physical Medicine & Rehabilitation·Y H WangI N Lien
May 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D E GarlandD A Weinstein
Nov 1, 1991·Paraplegia·M S NashJ D Shea
May 17, 1990·The New England Journal of Medicine·M B BrackenJ Maroon
May 1, 1984·Calcified Tissue International·P MinaireP J Meunier
Jun 1, 1995·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P D TsitourasW A Bauman
Mar 1, 1993·Psychosomatic Medicine·R DesharnaisG Godin
Apr 1, 1993·Metabolism: Clinical and Experimental·T S HuangY N Lien
Jan 1, 1996·American Journal of Physical Medicine & Rehabilitation·K K BeDellC F Kunkel
Jan 1, 1996·Advances in Experimental Medicine and Biology·M T HopmanB Oeseburg
Jan 1, 1997·Spinal Cord·T MohrM Kjaer
Mar 1, 1997·Archives of Physical Medicine and Rehabilitation·E G PearsonS Ludwig
Jan 1, 1997·The Journal of Spinal Cord Medicine·J H Frisbie
Jul 1, 1997·Calcified Tissue International·T MohrM Kjaer
Jul 1, 1997·Archives of Physical Medicine and Rehabilitation·J I MechanickK T Ragnarsson
Apr 29, 1998·American Journal of Physical Medicine & Rehabilitation·T S HuangJ S Lai
Apr 29, 1998·American Journal of Physical Medicine & Rehabilitation·J MukandS Biener-Bergman
Jul 22, 1998·Spinal Cord·J C BaldiW J Mysiw
Oct 17, 1998·Spinal Cord·L M JonesD F Gerrard
Oct 17, 1998·Spinal Cord·S JaovisidhaL J Deftos
Dec 5, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N HjeltnesH Wallberg-Henriksson
Dec 16, 1998·Spinal Cord·P VestergaardL Mosekilde
Feb 20, 1999·Archives of Physical Medicine and Rehabilitation·E D de BruinE Stüssi
Jul 29, 2000·Bone·M DautyJ F Mathe
Feb 13, 2001·Clinical Physiology·H L GerritsA de Haan
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H H Bolotin, H Sievänen
Nov 13, 2001·Bone·S J WardenJ D Wark
Dec 18, 2001·Journal of Applied Physiology·R J TalmadgeG A Dudley
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clinton RubinYi-Xian Qin
Mar 22, 2002·Calcified Tissue International·Y GuS J Publicover
Apr 12, 2002·The Journal of Spinal Cord Medicine·B ChenA Stein
May 17, 2002·Journal of Applied Physiology·Cécile R L BootMaria T E Hopman
Apr 26, 2003·European Journal of Clinical Investigation·P EserE Stüssi
Oct 15, 2003·Circulation·Miriam KooijmanMaria T E Hopman
Dec 4, 2003·Medicine and Science in Sports and Exercise·Patricia C E De GrootMaria T E Hopman
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kate WardZulf Mughal
Apr 24, 2004·Spine·Liqun YangMounir N Ghabriel
May 4, 2004·Bone·P EserH Schiessl
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yvonne ZehnderKurt Lippuner
Nov 10, 2004·Spinal Cord·T QianM L Sipski
Feb 9, 2005·Spinal Cord·C M Moran de BritoH Sakamoto
Apr 7, 2005·Calcified Tissue International·L MaïmounJ-L Leroux
Jun 15, 2005·Archives of Physical Medicine and Rehabilitation·Emiliana BizzariniAgostino Zampa
Citations
Dec 22, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S Dudley-JavoroskiR K Shields
Jul 1, 2007·Topics in Spinal Cord Injury Rehabilitation·Maureen C AsheUNKNOWN the SCIRE Research Team
Nov 28, 2013·PloS One·Ke-Vin ChangDer-Sheng Han
Feb 15, 2013·Journal of Rehabilitation Research and Development·Shauna Dudley-Javoroski, Richard K Shields
Jan 28, 2009·Spinal Cord·F Biering-SørensenB S B Lee
Dec 14, 2011·Spinal Cord·M P Galea
Jul 11, 2012·Spinal Cord·S R SilvermanC S Bickel
May 12, 2012·European Journal of Applied Physiology·Alfredo Arija-BlázquezJosé Florensa-Vila
Oct 8, 2013·European Journal of Applied Physiology·Todd Anthony AstorinoKara A Witzke
Mar 7, 2009·Journal of Neurologic Physical Therapy : JNPT·Amira E TawashyChihya Hung
Sep 9, 2015·Spinal Cord·M G PanissetD El-Ansary
Jun 15, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Christian Alexandre, Laurence Vico
Dec 15, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Suzanne L GroahInger Ljungberg
Dec 1, 2009·Best Practice & Research. Clinical Rheumatology·C Kok, P N Sambrook
Jul 16, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Margaret J HenryGeoffrey C Nicholson
Apr 29, 2008·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·L GriffinJ L Ivy
Mar 19, 2015·Journal of Osteoporosis·Simon von StengelWolfgang Kemmler
Oct 5, 2013·The Journal of Spinal Cord Medicine·Alfredo Arija-BlázquezJosé Florensa-Vila
Jul 9, 2014·The Journal of Spinal Cord Medicine·Ashraf S GorgeyDavid R Gater
Jan 8, 2015·Trials·Mary P GaleaLeonid Churilov
Apr 29, 2008·Bone·Angela FrotzlerPrisca Eser
Feb 28, 2017·Scientific Reports·Yufei TangKang Zhao
Mar 15, 2018·The Journal of Spinal Cord Medicine·Daniela G L Terson de PalevilleClaudia A Angeli
Sep 18, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Vishnu D ChandranSaikat Pal
Aug 27, 2017·Current Osteoporosis Reports·Jillian M Clark, David M Findlay
May 21, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Argyrios StampasMichael W O'Dell
May 11, 2018·The Journal of Spinal Cord Medicine·Nour ZleikLaura Carbone
Nov 2, 2019·JBMR Plus·Adina E DraghiciSandra J Shefelbine
May 13, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Saeed Soleyman-JahiVafa Rahimi-Movaghar
Sep 11, 2019·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Leslie R MorseBeverley C Craven
Jul 25, 2021·Journal of Neuroengineering and Rehabilitation·Kristen GelenitisRonald Triolo